Flowers Elena, Kanaya Alka M, Zhang Li, Aouizerat Bradley E
University of California, San Francisco, Department of Physiological Nursing, San Francisco, CA, United States.
University of California, San Francisco, Institute for Human Genetics, San Francisco, CA, United States.
Front Genet. 2022 Mar 18;13:853633. doi: 10.3389/fgene.2022.853633. eCollection 2022.
Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European and East Asian racial or ethnic groups, however, ancestry was not typically reported. We evaluated the risk for type 2 diabetes as an exemplar to show that race and ethnic group may contribute to inconsistent validation of previous findings of associations with microRNAs.
先前聚焦于循环微RNA与复杂疾病风险的研究结果并不一致。大多数研究聚焦于欧洲和东亚种族或族裔群体，然而，祖先信息通常并未报告。我们以2型糖尿病风险评估为例，以表明种族和族裔群体可能导致先前关于微RNA关联研究结果验证的不一致。
