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多糖对肠道菌群的调节作用:维持正常认知功能及治疗抑郁症的可行方法

Polysaccharide Regulation of Intestinal Flora: A Viable Approach to Maintaining Normal Cognitive Performance and Treating Depression.

作者信息

Wang Xinzhou, Cheng Lu, Liu Yanan, Zhang Ruilin, Wu Zufang, Weng Peifang, Zhang Peng, Zhang Xin

机构信息

Department of Food Science and Engineering, Ningbo University, Ningbo, China.

Department of Food Science, Rutgers, The State University of New Jersey, Newark, NJ, United States.

出版信息

Front Microbiol. 2022 Mar 11;13:807076. doi: 10.3389/fmicb.2022.807076. eCollection 2022.

Abstract

The intestinal tract of a healthy body is home to a large variety and number of microorganisms that will affect every aspect of the host's life. In recent years, polysaccharides have been found to be an important factor affecting intestinal flora. Polysaccharides are widely found in nature and play a key role in the life activities of living organisms. In the intestinal tract of living organisms, polysaccharides have many important functions, such as preventing the imbalance of intestinal flora and maintaining the integrity of the intestinal barrier. Moreover, recent studies suggest that gut microbes can influence brain health through the brain-gut axis. Therefore, maintaining brain health through polysaccharide modulation of gut flora deserves further study. In this review, we outline the mechanisms by which polysaccharides maintain normal intestinal flora structure, as well as improving cognitive function in the brain the brain-gut axis by virtue of the intestinal flora. We also highlight the important role that gut microbes play in the pathogenesis of depression and the potential for treating depression through the use of polysaccharides to modulate the intestinal flora.

摘要

健康机体的肠道是种类繁多、数量庞大的微生物的家园,这些微生物会影响宿主生活的方方面面。近年来,多糖被发现是影响肠道菌群的一个重要因素。多糖在自然界中广泛存在,在生物体的生命活动中起着关键作用。在生物体的肠道中,多糖具有许多重要功能,如防止肠道菌群失衡和维持肠道屏障的完整性。此外,最近的研究表明,肠道微生物可通过脑-肠轴影响大脑健康。因此,通过多糖调节肠道菌群来维持大脑健康值得进一步研究。在这篇综述中,我们概述了多糖维持正常肠道菌群结构的机制,以及借助肠道菌群通过脑-肠轴改善大脑认知功能的机制。我们还强调了肠道微生物在抑郁症发病机制中所起的重要作用,以及通过使用多糖调节肠道菌群来治疗抑郁症的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/8966502/e54518dabe1a/fmicb-13-807076-g001.jpg

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