Esmaeilzadeh Hossein, Eskandarisani Mehrdad, Nabavizadeh Hesamedin, Alyasin Soheila, Vali Mouhebat, Mortazavi Negar
Allergy Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Postepy Dermatol Alergol. 2022 Feb;39(1):121-125. doi: 10.5114/ada.2022.113805. Epub 2022 Feb 28.
Chronic spontaneous urticaria (CSU) is a common skin allergic reaction with an unknown mechanism. There is inadequate evidence to support the role of aeroallergen sensitization in CSU.
The present study was conducted to investigate the association between the aeroallergen sensitivity and CSU.
In this cross-sectional study, 91 patients with CSU were recruited. Information on demographic characteristics was collected. The skin prick test (SPT) for most prevalent aeroallergens and pulmonary function test (PFT) were performed and the results were clinically matched to investigate the allergic rhinitis (AR) and asthma. Total serum immunoglobulin E (IgE) concentration was analysed in the subjects for the presence of atopy.
Ninety one patients (75 of them were females) were enrolled in the study (with a mean age of 36.90 ±12.93 years). SPT result was positive in 75 (82.4%) subjects. Weeds (67 cases, 73.6%), trees (61 cases, 67%), and dust mites (55 cases, 60.4%) were the most common pollens in the positive SPT samples. Thirty-seven (40.7%) of the patients had allergic rhinitis. There was a statistically significant association between the presence of AR and positive SPT result ( = 0.002). Eight patients had allergic asthma and 45 (49.4%) of the patients had a total serum IgE level of more than 100 IU/ml.
Our results indicated a clear association between the presence of aeroallergen sensitivity and development of CSU. AR exists as a co-morbidity of CSU.
慢性自发性荨麻疹（CSU）是一种机制不明的常见皮肤过敏反应。目前尚无充分证据支持气传变应原致敏在CSU中的作用。
本研究旨在探讨气传变应原敏感性与CSU之间的关联。
在这项横断面研究中，招募了91例CSU患者。收集了人口统计学特征信息。对最常见的气传变应原进行了皮肤点刺试验（SPT）和肺功能测试（PFT），并将结果进行临床匹配以调查过敏性鼻炎（AR）和哮喘。分析了受试者血清总免疫球蛋白E（IgE）浓度以检测特应性的存在。
91例患者（其中75例为女性）纳入研究（平均年龄36.90±12.93岁）。75例（82.4%）受试者的SPT结果为阳性。杂草（67例，73.6%）、树木（61例，67%）和尘螨（55例，60.4%）是SPT阳性样本中最常见的变应原。37例（40.7%）患者患有过敏性鼻炎。AR的存在与SPT阳性结果之间存在统计学显著关联（P = 0.002）。8例患者患有过敏性哮喘，45例（49.4%）患者的血清总IgE水平超过100 IU/ml。
我们的结果表明气传变应原敏感性的存在与CSU的发生之间存在明显关联。AR作为CSU的合并症存在。
