从朝鲜淫羊藿中提取的新型抗肺纤维化类黄酮糖苷。
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum.
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi 117004, China.
出版信息
Chin J Nat Med. 2022 Mar;20(3):221-228. doi: 10.1016/S1875-5364(21)60116-4.
Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities.
从朝鲜淫羊藿（Epimedium koreanum Nakai）的叶子中分离得到了 4 个新的prenylflavonoid 糖苷，即 koreanoside H-K（1-4），以及 11 个已知的化合物（5-15）。通过 1D NMR、2D NMR、HR-ESI-MS、IR 和 UV 确定了它们的结构。通过酸水解和它们的衍生物的 HPLC 分析确定了糖部分的结构。值得注意的是，化合物 3 和化合物 4 被阐明含有岩藻糖和奎诺糖部分，这是淫羊藿属中两个极其罕见的糖单位。使用 A549 细胞系评估了新化合物的抗肺纤维化活性。化合物 1、2 和 4 显示出显著的抗肺纤维化活性。
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