School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi 117004, China.
Chin J Nat Med. 2022 Mar;20(3):221-228. doi: 10.1016/S1875-5364(21)60116-4.
Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities.
从朝鲜淫羊藿（Epimedium koreanum Nakai）的叶子中分离得到了 4 个新的prenylflavonoid 糖苷，即 koreanoside H-K（1-4），以及 11 个已知的化合物（5-15）。通过 1D NMR、2D NMR、HR-ESI-MS、IR 和 UV 确定了它们的结构。通过酸水解和它们的衍生物的 HPLC 分析确定了糖部分的结构。值得注意的是，化合物 3 和化合物 4 被阐明含有岩藻糖和奎诺糖部分，这是淫羊藿属中两个极其罕见的糖单位。使用 A549 细胞系评估了新化合物的抗肺纤维化活性。化合物 1、2 和 4 显示出显著的抗肺纤维化活性。
