School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P.R. China.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Nat Prod Res. 2024 Oct;38(19):3336-3343. doi: 10.1080/14786419.2023.2246631. Epub 2023 Sep 3.
Two new prenylated flavonol glycosides, namely Desmethylicaritin-3---D-glucopyranosyl-(1→3)--L(4″--acetyl) rhamnopyranosyl-7---D(6''''--acetyl)-glucopyranoside () and 5,7,3',4'-tetrahydroxyl-8-(3,3-dimethylallyl)-flavonol-3---L-rhamnopyranoside (), and one with no NMR spectral data reported () were isolated from Nakai. Their structures were elucidated by 1D, 2D NMR and HRESIMS analysis. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. The anti-pulmonary fibrosis activities result showed that compound had significant inhibitory effects on A549 cell fibrosis, which was similar to that of the positive control drug, pirfenidone.
从山麦冬中分离得到两个新的苯丙素黄酮醇糖苷，分别为去甲异甘草素-3---D-吡喃葡萄糖基-(1→3)--L(4″--乙酰基)鼠李吡喃糖基-7---D(6''''--乙酰基)-吡喃葡萄糖苷()和 5,7,3',4'-四羟基-8-(3,3-二甲基烯丙基)-黄酮醇-3---L-鼠李吡喃糖苷()，以及一个没有报道 NMR 谱数据的化合物()。它们的结构通过 1D、2D NMR 和 HRESIMS 分析阐明。糖部分的鉴定通过酸水解和它们的衍生物的 HPLC 分析进行。抗肺纤维化活性结果表明，化合物对 A549 细胞纤维化具有显著的抑制作用，与阳性对照药物吡非尼酮相似。
