环状RNA对缺血性中风的影响。
Impact of CircRNAs on Ischemic Stroke.
作者信息
Liu Miaomiao, Liu Xiaolin, Zhou Maorong, Guo Shao, Sun Kai
机构信息
1Department of Radiology, The Third People's Hospital of Long Gang District, Shenzhen, China.
2Graduate School of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China.
出版信息
Aging Dis. 2022 Apr 1;13(2):329-339. doi: 10.14336/AD.2021.1113. eCollection 2022 Apr.
Abstract
Circular RNA (circRNA) is a recently discovered class of endogenous non-coding RNA that is generated by cyclization, driven by intron pairing, and regulated by related regulators. An important biological function of CircRNA is acting as a molecular sponge to significantly alter miRNA levels over a short period. Several studies have shown that circRNA is closely related to stroke. Therefore, a better understanding of CircRNA function and regulatory mechanism in ischemic brain will help us for the early detection, early diagnosis, and early treatment of stroke. Here, we summary the biological characteristics, expression of circRNA, and its effect on outcome after ischemic stroke.
摘要
环状RNA（circRNA）是最近发现的一类内源性非编码RNA，它通过环化产生，由内含子配对驱动，并受相关调节因子调控。CircRNA的一个重要生物学功能是作为分子海绵，在短时间内显著改变miRNA水平。多项研究表明，circRNA与中风密切相关。因此，更好地了解CircRNA在缺血性脑损伤中的功能和调控机制将有助于我们对中风进行早期检测、早期诊断和早期治疗。在此，我们总结了circRNA的生物学特性、表达及其对缺血性中风后预后的影响。
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2
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