Clark Abigale L, Williams Blake
College of Osteopathic Medicine, Kansas City University of Medicine and Biosciences, Kansas City, USA.
Dermatology, Premier Dermatology, Bentonville, USA.
Cureus. 2022 Feb 26;14(2):e22625. doi: 10.7759/cureus.22625. eCollection 2022 Feb.
Pyoderma gangrenosum (PG) is a rare inflammatory skin disease of unknown origin. As with other vaccines, COVID-19 vaccines have been associated with many cutaneous reactions. Although COVID-19 vaccination is crucial, it is important for dermatologists and other physicians to be aware of the possible cutaneous reactions that can occur following COVID-19 vaccination. In this report, we describe a 73-year-old woman with a personal history of PG who experienced a recurrence after receiving her second dose of the tozinameran vaccine. Although extremely rare, flares of other inflammatory dermatoses, including lichen planus, have been reported following COVID-19 vaccination. Here we discuss the overlap in pathogenesis of PG and COVID-19, proposing possible mechanisms behind this rare phenomenon.
坏疽性脓皮病（PG）是一种病因不明的罕见炎症性皮肤病。与其他疫苗一样，新冠病毒疫苗与多种皮肤反应相关。尽管接种新冠病毒疫苗至关重要，但皮肤科医生和其他医生了解接种新冠病毒疫苗后可能出现的皮肤反应也很重要。在本报告中，我们描述了一名73岁有PG个人病史的女性，在接种第二剂托珠单抗疫苗后病情复发。尽管极为罕见，但也有报告称接种新冠病毒疫苗后出现了包括扁平苔藓在内的其他炎症性皮肤病的病情加重情况。在此，我们讨论PG与新冠病毒发病机制的重叠之处，提出这一罕见现象背后的可能机制。
