皮肤抗原特性的区域差异。皮肤病变疾病特异性分布的一个可能原因。
Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions.
作者信息
Sison-Fonacier L, Bystryn J C
出版信息
J Exp Med. 1986 Dec 1;164(6):2125-30. doi: 10.1084/jem.164.6.2125.
Abstract
The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expression of both antigens was relatively stable within the same region, but varied between regions in a pattern that was distinct for each antigen. For each antigen there was a correlation between regions of high expression and location of skin lesions in autoimmune diseases involving the antigen. The results indicate that there are marked regional differences in the antigenic properties of skin and suggest this may influence the distribution of cutaneous lesions in some skin diseases.
摘要
通过绘制寻常型天疱疮和大疱性类天疱疮这两种皮肤特异性抗原在身体不同部位的表达图谱，研究了某些皮肤病中皮肤病变分布可能是由于皮肤抗原特性差异所致的可能性。在同一部位，这两种抗原的表达相对稳定，但在不同部位之间存在差异，且每种抗原的差异模式各不相同。对于每种抗原，在涉及该抗原的自身免疫性疾病中，高表达区域与皮肤病变位置之间存在相关性。结果表明，皮肤的抗原特性存在显著的区域差异，并提示这可能影响某些皮肤病中皮肤病变的分布。
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