Nie Xiaojing, Zhang Xueyan, Lei Baozhen, Shi Yonghua, Yang Jingxin
Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, China.
Beijing Engineering Research Center of Smart Mechanical Innovation Design Service, Beijing Union University, Beijing, China.
Front Bioeng Biotechnol. 2022 Mar 14;10:842706. doi: 10.3389/fbioe.2022.842706. eCollection 2022.
Despite magnesium based metal materials are widely used in bone defect repair, there are still various deficiencies, and their properties need to be optimized. Composites synthesized with magnesium based metal as matrix are the research hotspot, and the host immune response after biomaterial implantation is very important for bone binding. By studying the immunoregulation of bone biomaterials, it can regulate the immune response in the process of osteogenesis and create a good local immune microenvironment, which is conducive to biomaterials to reduce inflammatory response and promote good bone binding. This article introduces the osteogenic mechanism of magnesium based metal materials and its regulation on bone immune microenvironment in detail.
尽管镁基金属材料在骨缺损修复中得到广泛应用，但仍存在各种不足，其性能有待优化。以镁基金属为基体合成的复合材料是研究热点，生物材料植入后的宿主免疫反应对骨结合非常重要。通过研究骨生物材料的免疫调节作用，可以在成骨过程中调节免疫反应，营造良好的局部免疫微环境，有利于生物材料减轻炎症反应，促进良好的骨结合。本文详细介绍了镁基金属材料的成骨机制及其对骨免疫微环境的调节作用。
