Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutr Cancer. 2022;74(9):3140-3145. doi: 10.1080/01635581.2022.2059089. Epub 2022 Apr 4.
There are limited prospective studies assessing the post-diagnosis nutritional status of patients with gastric cancer (GC). This study aimed to assess the association between nutritional status and three-year survival of patients with GC.
In this prospective study, we included all histologically confirmed GC patients admitted to the Imam Reza Hospital in Tabriz, Iran from September 2016 to October 2019. The nutritional status of patients was assessed using the Patient-Generated Subjective Global Assessment (PG-SGA) form. All patients were followed up every six months for three years. The overall survival (OS) was calculated from the diagnosis date to the date of death or last visit.
In this study, 302 patients (mean age: 67.39 ± 12.04 years) with GC were included. The median OS was 11.00 mo, (95% CI: 80.03, 13.96). Only 28.4% of patients were well-nourished, and survived significantly longer than malnourished patients (20.5 vs. 8 mo, = 0.01). The mortality hazard rate in patients with moderate and severe malnutrition was 2.04 times higher than well-nourished patients.
According to our results, the nutrition status of GC patients at the time of diagnosis was independently associated with their survival rate.
目前评估胃癌（GC）患者确诊后营养状况的前瞻性研究有限。本研究旨在评估 GC 患者营养状况与 3 年生存率之间的关系。
本前瞻性研究纳入了 2016 年 9 月至 2019 年 10 月期间在伊朗大不里士伊玛目礼萨医院住院的所有经组织学证实的 GC 患者。采用患者主观整体评估（PG-SGA）表评估患者的营养状况。所有患者每 6 个月随访 3 年。总生存期（OS）从诊断日期计算至死亡或最后一次就诊日期。
本研究共纳入 302 例 GC 患者（平均年龄：67.39±12.04 岁）。中位 OS 为 11.00 个月（95%CI：80.03，13.96）。仅有 28.4%的患者营养状况良好，且明显比营养不良患者存活时间更长（20.5 与 8 个月，=0.01）。中重度营养不良患者的死亡危险率是营养状况良好患者的 2.04 倍。
根据我们的研究结果，GC 患者在确诊时的营养状况与生存率独立相关。
