串联重复的上游控制序列介导酿酒酵母铜金属硫蛋白基因的铜诱导转录。
Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene.
作者信息
Thiele D J, Hamer D H
出版信息
Mol Cell Biol. 1986 Apr;6(4):1158-63. doi: 10.1128/mcb.6.4.1158-1163.1986.
Abstract
Transcription of the Saccharomyces cerevisiae copper-metallothionein gene, CUP1, inducible by copper. By analyzing deletion and fusion mutants in the CUP1 5'-flanking region, we identified two closely related, tandemly arranged copper regulatory elements. A synthetic version of one of these elements conferred efficient copper induction on a heterologous promoter when present in two tandem copies.
摘要
酿酒酵母铜金属硫蛋白基因CUP1的转录受铜诱导。通过分析CUP1 5'侧翼区域的缺失和融合突变体，我们鉴定出两个紧密相关、串联排列的铜调控元件。当以两个串联拷贝存在时，其中一个元件的合成版本赋予了异源启动子高效的铜诱导能力。
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