Zelenin V N
Probl Endokrinol (Mosk). 1986 Sep-Oct;32(5):59-61.
The effect of atropine on insulin secretion stimulated by glucose administration in the duodenum was studied in chronic experiments on dogs prior to and following supradiaphragmatic vagotomy. The control experiments on 10 dogs have demonstrated that in the first 10 min. after glucose administration in the duodenum pancreatic islet B-cells show a raised sensitivity to glucose expressed in a higher value of the insulinogenic index at this time than in later periods. After vagotomy no significant differences in insulin secretion and glucose tolerance in animals were found as compared to preoperative values. However the experiments with atropine administration have shown that the blockade of M-choline receptors results in considerable weakening of insulin secretion and glucose tolerance in animals irrespective of the integrity of the nerves vagus. It has been assumed that an important role in the mechanisms of the intestinoinsular axis is played by the nervous connections of the duodenum with the pancreas through interaction of the intraorganic neurons of these organs.
在膈上迷走神经切断术前和术后，对犬进行慢性实验，研究阿托品对十二指肠给予葡萄糖刺激胰岛素分泌的影响。对10只犬的对照实验表明，十二指肠给予葡萄糖后的最初10分钟内，胰岛B细胞对葡萄糖的敏感性升高，此时胰岛素生成指数的值高于随后的时间段。迷走神经切断术后，与术前值相比，动物的胰岛素分泌和葡萄糖耐量没有显著差异。然而，给予阿托品的实验表明，无论迷走神经是否完整，M胆碱受体的阻断都会导致动物胰岛素分泌和葡萄糖耐量显著减弱。据推测，十二指肠与胰腺通过这些器官的器官内神经元相互作用形成的神经连接在肠胰岛轴机制中起重要作用。
