Chen Xiaomin, Zhou Xiangxiang, Wang Xin
Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, China.
School of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Exp Hematol Oncol. 2022 Apr 5;11(1):21. doi: 10.1186/s40164-022-00269-y.
YT521-B homology domain family member 2 (YTHDF2) is an N-methyladenosine (mA)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor progression. Furthermore, YTHDF2 is closely associated with the proliferation, apoptosis, invasion, and migration of tumor cells, suggesting its significant role in cancers. YTHDF2 primarily relies on mA modification to modulate signaling pathways in cancer cells. However, the expression and function of YTHDF2 in human malignancies remain controversial. Meanwhile, the underlying molecular mechanisms of YTHDF2 have not been elucidated. In this review, we principally summarized the biological functions and molecular mechanisms of YTHDF2 in tumors and discussed its prognostic and therapeutic values.
YT521 - B同源结构域家族成员2（YTHDF2）是一种N - 甲基腺苷（mA）结合蛋白，最初被发现可调节mRNA的稳定性。越来越多的证据表明，YTHDF2可参与多种生物过程，包括胚胎发育、免疫反应和肿瘤进展。此外，YTHDF2与肿瘤细胞的增殖、凋亡、侵袭和迁移密切相关，表明其在癌症中具有重要作用。YTHDF2主要依赖mA修饰来调节癌细胞中的信号通路。然而，YTHDF2在人类恶性肿瘤中的表达和功能仍存在争议。同时，YTHDF2的潜在分子机制尚未阐明。在本综述中，我们主要总结了YTHDF2在肿瘤中的生物学功能和分子机制，并讨论了其预后和治疗价值。
