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氯胺酮复合局部麻醉药用于小儿术后镇痛的骶管阻滞临床证据综述

Review of clinical evidence of caudal block for postoperative analgesia in children with ketamine added local anesthetics.

作者信息

Endeshaw Amanuel Sisay, Aligaz Esubalew Muluneh, Molla Misganew Terefe, Mekonnen Befekadu Amare, Tesema Abdi Tariku, Dinku Tesfaye Abebe, Atero Kirubel Behailu, Regassa Tsion Lemma

机构信息

Department of Anesthesia, College of Medicine and Health Science, Bahirdar University, Bahirdar, Ethiopia.

Department of Anesthesiology, College of Medicine and Health Science, Dilla University, Ethiopia.

出版信息

Ann Med Surg (Lond). 2022 Mar 8;75:103480. doi: 10.1016/j.amsu.2022.103480. eCollection 2022 Mar.

DOI:10.1016/j.amsu.2022.103480
PMID:35386802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8978094/
Abstract

BACKGROUND

Adding ketamine to local anesthetics used for caudal block in children is an emerging clinical practice. This review aims to resolve controversies related to this adjuvant for a caudal block in children who underwent sub-umbilical surgeries.

METHODS

Between January 2010 and November 2021, PubMed, Cochrane Review, and Google Scholar were searched for a caudal block with ketamine added local anesthetics for children. After screening for eligibility and removing duplicates, 38,187 articles were found, 13 reviewed.

DISCUSSION

Despite adding ketamine to local anesthetics used for a caudal block, it is a recent technique practiced worldwide. Ketamine showed equi-efficacious as other adjuvants used for the caudal block to control postoperative pain in children.

CONCLUSION

Ketamine with a 0.5 mg/kg dose is safe and effective to manage postoperative children's pain when used as an adjuvant to local anesthetics used for caudal block.

摘要

背景

在用于儿童骶管阻滞的局部麻醉剂中添加氯胺酮是一种新兴的临床实践。本综述旨在解决与这种用于接受脐下手术儿童骶管阻滞辅助剂相关的争议。

方法

在2010年1月至2021年11月期间,检索了PubMed、Cochrane综述和谷歌学术,以查找在儿童局部麻醉剂中添加氯胺酮进行骶管阻滞的相关内容。在筛选合格文章并去除重复项后,共找到38187篇文章,其中13篇进行了综述。

讨论

尽管在用于骶管阻滞的局部麻醉剂中添加氯胺酮是一种最近在全球范围内应用的技术。氯胺酮在控制儿童术后疼痛方面与用于骶管阻滞的其他辅助剂显示出同等疗效。

结论

当氯胺酮以0.5mg/kg的剂量作为用于骶管阻滞的局部麻醉剂的辅助剂时,对管理儿童术后疼痛是安全有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c03/8978094/318e1fcc5f5f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c03/8978094/318e1fcc5f5f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c03/8978094/318e1fcc5f5f/gr1.jpg

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Br J Anaesth. 2019 Apr;122(4):509-517. doi: 10.1016/j.bja.2018.11.030. Epub 2019 Feb 1.
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A randomized-controlled, double-blind study to evaluate the efficacy of caudal midazolam, ketamine and neostigmine as adjuvants to bupivacaine on postoperative analgesic in children undergoing lower abdominal surgery.一项随机对照双盲研究,旨在评估氯胺酮、咪达唑仑和新斯的明作为布比卡因辅助剂对下腹部手术患儿术后镇痛的效果。
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