Gao Liheng, Xu Mingxi, Zhao Wenshuo, Zou Ting, Wang Fujun, Da Jun, Wang Yiwei, Wang Lu
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200011, China.
Bioact Mater. 2022 Mar 22;18:128-137. doi: 10.1016/j.bioactmat.2022.03.025. eCollection 2022 Dec.
During the postoperative management of urinary diseases, oral or intravenous administration of drugs and implanting ureteral stents are usually required, making localized drug delivery by ureteral stent a precise and effective medication strategy. In the traditional drug loading method, the drug was premixed in the implants in production lines and the versatility of drugs was restricted. However, the complex situation in the urinary system fails the possibility of finding a "one fits all" medication plan, and the intraoperative drug-loading of implants is highly desired to support customized therapy. Here, we designed an ultrathin (8 μm), elastic, and self-adhesive nanofiber bio-tape (NFBT) that can easily encapsulate drugs on the stent surface for controllable localized drug delivery. The NFBT exhibited high binding strength to a ureteral stent, a sustained release over 7 d in PBS for hydrophilic drug, and a zero-order release curve over 28 days for the hydrophobic drug nitrofurantoin (NFT). Further in vivo experiments using a porcine ureteral tract infection model demonstrated that NFBT loaded with NFT could significantly reduce the bacterial concentration in urine. The total amount of NFT delivered by the NFBT was about 2.68 wt% of the recommended dose for the systemic administration.
在泌尿系统疾病的术后管理中，通常需要口服或静脉给药以及植入输尿管支架，这使得通过输尿管支架进行局部给药成为一种精确有效的用药策略。在传统的载药方法中，药物在生产线的植入物中预先混合，药物的通用性受到限制。然而，泌尿系统的复杂情况使得找到一个“一刀切”的用药方案变得不可能，因此非常需要在术中对植入物进行载药以支持定制化治疗。在此，我们设计了一种超薄（8μm）、有弹性且自粘的纳米纤维生物胶带（NFBT），它可以轻松地在支架表面包裹药物，实现可控的局部给药。NFBT对输尿管支架表现出高结合强度，亲水性药物在PBS中可持续释放7天，疏水性药物呋喃妥因（NFT）在28天内呈现零级释放曲线。进一步使用猪输尿管感染模型进行的体内实验表明，负载NFT的NFBT可以显著降低尿液中的细菌浓度。NFBT输送的NFT总量约为全身给药推荐剂量的2.68 wt%。
