Funakoshi A, Nakano I, Shinozaki H, Tateishi K, Hamaoka T, Ibayashi H
Am J Gastroenterol. 1986 Dec;81(12):1174-8.
Plasma cholecystokinin (CCK) responses after ingestion of a test meal in patients with mild chronic pancreatitis having abdominal pain were studied with a radioimmunoassay using the CCK specific antiserum (OAL-656) produced by a novel immunization procedure. Mean concentration of the fasting plasma CCK determined using CCK-8 as a standard was 31.5 +/- 5.8 pg/ml in six patients who had mild impaired exocrine function with pain, and was significantly higher than 10 healthy subjects (9.8 +/- 1.8 pg/ml). In those patients, the ingestion of a liquid test meal led to a peak of 75.1 +/- 25.4 pg/ml at 30 min, and the 120-min integrated CCK response (5427 +/- 1217.3 pg X min/ml) was significantly higher than in healthy subjects (1538 +/- 110.1 pg X min/ml).
采用一种新型免疫程序制备的胆囊收缩素（CCK）特异性抗血清（OAL - 656），通过放射免疫分析法研究了轻度慢性胰腺炎伴腹痛患者摄入试验餐前后血浆CCK的反应。以CCK - 8为标准测定的6例轻度外分泌功能受损且伴有疼痛的患者空腹血浆CCK平均浓度为31.5±5.8 pg/ml，显著高于10名健康受试者（9.8±1.8 pg/ml）。在这些患者中，摄入液体试验餐后30分钟时血浆CCK峰值达到75.1±25.4 pg/ml，120分钟的CCK综合反应（5427±1217.3 pg·min/ml）显著高于健康受试者（1538±110.1 pg·min/ml）。
