Garcés M C, Gómez-Cerezo J, Codoceo R, Grande C, Barbado J, Vázquez J J
Department of Internal Medicine, La Paz Hospital, Autónoma University of Madrid, Spain.
Dig Dis Sci. 1998 Mar;43(3):562-6. doi: 10.1023/a:1018815225100.
Cholecystokinin (CCK) response to a test meal should be increased in patients with pancreatic insufficiency, as trypsin is absent from the duodenum. If pancreatic enzymes are added, a restoration of the inhibitory feedback should result in lower levels of CCK. Ten patients with chronic pancreatitis and steatorrhea were studied. CCK basal and postprandial levels were evaluated the day before and 45 and 90 days after treatment with oral pancreatin. Twelve healthy volunteers were included as reference group. CCK basal levels did not vary. CCK response to a test meal was increased in patients before treatment and diminished when oral enzymes were maintained for months even after three days of therapy withdrawal. We conclude that long-term therapy with oral enzymes induces changes in CCK response that do not regress after three days of treatment suspension.
在胰腺功能不全的患者中，由于十二指肠中缺乏胰蛋白酶，胆囊收缩素（CCK）对试餐的反应应该增强。如果添加胰酶，抑制性反馈的恢复应该会导致CCK水平降低。对10例慢性胰腺炎和脂肪泻患者进行了研究。在口服胰酶治疗前、治疗后45天和90天评估CCK的基础水平和餐后水平。纳入12名健康志愿者作为参照组。CCK基础水平没有变化。患者在治疗前对试餐的CCK反应增强，即使在停药三天后，口服酶维持数月时该反应也会减弱。我们得出结论，口服酶的长期治疗会引起CCK反应的变化，在停药三天后这种变化不会消退。
