Pirson Y, van Ypersele de Strihou C
Am J Kidney Dis. 1986 Nov;8(5):338-44. doi: 10.1016/s0272-6386(86)80108-1.
Nonsteroidal antiinflammatory drugs (NSAIDs) induce a variety of renal side effects. We review their prevalence and clinical relevance, and identify the patients who are most at risk for these complications. NSAIDs induce hemodynamic renal failure in states of compromised renal perfusion and in the presence of a preexisting nephropathy. Association of triamterene and indomethacin is especially nephrotoxic and should be avoided. NSAIDs cause sodium retention and impair the natriuretic effect of diuretics: this side effect is clinically relevant in edema-forming states. Hyperkalemia induced by NSAIDs is harmful in case of renal failure and hypoaldosteronism. NSAIDs may induce an acute interstitial nephritis often associated with the nephrotic syndrome; the event is rare and unpredictable, and mainly propionic acid derivatives have been incriminated. NSAIDs are reported to attenuate the hypotensive effect of various drugs; further studies are warranted to better delineate the clinical relevance of this observation.
非甾体抗炎药（NSAIDs）会引发多种肾脏副作用。我们回顾了它们的发生率及临床相关性，并确定了发生这些并发症风险最高的患者群体。NSAIDs在肾灌注受损状态以及存在基础肾病的情况下会引发血流动力学性肾衰竭。氨苯蝶啶与吲哚美辛联用尤其具有肾毒性，应避免使用。NSAIDs会导致钠潴留并削弱利尿剂的利钠作用：这种副作用在水肿形成状态下具有临床相关性。NSAIDs诱发的高钾血症在肾衰竭和醛固酮减少症的情况下是有害的。NSAIDs可能会引发急性间质性肾炎，常与肾病综合征相关；这种情况罕见且不可预测，主要涉及的是丙酸衍生物。据报道，NSAIDs会减弱多种药物的降压作用；有必要进行进一步研究以更好地阐明这一观察结果的临床相关性。
