Webb M S, Milner A D, Hiller E J, Henry R L
Arch Dis Child. 1986 Nov;61(11):1108-10. doi: 10.1136/adc.61.11.1108.
We compared nebulised beclomethasone dipropionate suspension against placebo in 16 children with moderately severe asthma in double blind crossover fashion. Three children withdrew due to deterioration while on placebo. Of the remaining 13, eight were better on beclomethasone and five on placebo. These trends in favour of nebulised beclomethasone were not significant and do not suggest that the suspension is as effective as inhaled powder or aerosol topical steroid formulation.
我们以双盲交叉方式,将丙酸倍氯米松雾化混悬液与安慰剂对16名中度重症哮喘儿童进行了比较。3名儿童在使用安慰剂期间因病情恶化而退出。在其余13名儿童中,8名使用倍氯米松后病情好转,5名使用安慰剂后病情好转。这些有利于丙酸倍氯米松雾化的趋势并不显著,也不表明该混悬液与吸入粉剂或气雾剂局部类固醇制剂一样有效。