Liu Shixu, Cui Xiangning, Xia Kun, Wang Dandan, Han Jing, Yao Xiaoyan, Liu Xiaohong, Bian Lingjie, Zhang Jinzhi, Li Guangxi
Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School of China Academy of Chinese Medical Sciences, Beijing, China.
Front Med (Lausanne). 2022 Mar 22;9:846480. doi: 10.3389/fmed.2022.846480. eCollection 2022.
Pulmonary alveolar proteinosis (PAP) is a rare syndrome first described by Rosen et al. in 1958. Despite our considerably evolved understanding of PAP over the past decades, no bibliometric studies have been reported on this field. We aimed to analyze and visualize the research hotspots and current trends of the PAP research field using a bibliometric analysis to help understand the future development of basic and clinical research.
The literature regarding PAP was culled from the Web of Science Core Collection (WoSCC) database. Data were extracted from the relevant articles and visually analyzed using CiteSpace and VOSviewer software.
Nine hundred and nine qualifying articles were included in the analysis. Publications regarding PAP increased over time. These articles mainly come from 407 institutions of 57 countries. The leading countries were the USA and Japan. University of Cincinnati (USA) and Niigata University (Japan) featured the highest number of publications among all institutions. Bruce C Trapnell exerts a significant publication impact and has made the most outstanding contributions in the field of PAP. was the journal with the most publications, and was the most commonly cited journal. All the top 5 co-cited journals belong to Q1. Keyword citation bursts revealed that inflammation, deficiency, tissue resident macrophage, classification, autoimmune pulmonary alveolar proteinosis, sarcoidosis, gm csf, high resolution ct, and fetal monocyte were the emerging research hotspots.
Research on PAP is prosperous. International cooperation is also expected to deepen and strengthen in the future. Our results indicated that the etiology and pathogenesis of PAP, current and emerging therapies, especially the novel pathogenesis-based options will remain research hotspots in the future.
肺泡蛋白沉积症（PAP）是一种罕见综合征，于1958年由罗森等人首次描述。尽管在过去几十年里我们对PAP的认识有了很大进展，但尚未有关于该领域的文献计量学研究报道。我们旨在通过文献计量学分析来分析和可视化PAP研究领域的热点和当前趋势，以帮助理解基础和临床研究的未来发展。
从科学网核心合集（WoSCC）数据库中筛选有关PAP的文献。从相关文章中提取数据，并使用CiteSpace和VOSviewer软件进行可视化分析。
909篇符合条件的文章纳入分析。关于PAP的出版物数量随时间增加。这些文章主要来自57个国家的407个机构。领先国家是美国和日本。美国辛辛那提大学和日本新潟大学在所有机构中发表的文章数量最多。布鲁斯·C·特拉普内尔产生了重大的出版影响力，在PAP领域做出了最杰出的贡献。 是发表文章最多的期刊， 是被引用最多的期刊。所有前5名的共被引期刊都属于Q1区。关键词共现分析显示，炎症、缺陷、组织驻留巨噬细胞、分类、自身免疫性肺泡蛋白沉积症、结节病、粒细胞巨噬细胞集落刺激因子、高分辨率CT和胎儿单核细胞是新兴的研究热点。
PAP的研究很繁荣。预计未来国际合作也将深化和加强。我们的结果表明，PAP的病因和发病机制、当前和新兴的治疗方法，尤其是基于新发病机制选择的治疗方法，将仍然是未来的研究热点。
