Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, 610041, China.
Exp Eye Res. 2023 Aug;233:109556. doi: 10.1016/j.exer.2023.109556. Epub 2023 Jun 27.
Interleukin-6 (IL-6) is a pleiotropic cytokine that participates in immunomodulation, inflammation, increases vascular permeability, hematopoiesis, and stimulates cell proliferation, among other biological processes. It exerts effects primarily through the classic and trans-signaling pathways. Many studies have demonstrated that IL-6 plays a critical role in the development of retinal diseases including diabetic retinopathy, uveitis, age-related macular degeneration, glaucoma, retinal vein occlusion, central serous chorioretinopathy and proliferative vitreoretinopathy. Thus, the progressive development of drugs targeting IL-6 and IL-6 receptor may play a role in the treatment of multiple retinal diseases. In this article, we comprehensively review the IL-6's biological functions of and its mechanisms in the pathogenesis of various retinal diseases. Furthermore, we summarize the drugs targeting IL-6 and its receptor and prospect their potential application in retinal diseases, hoping to provide new ideas for the treatment of retinal diseases.
白细胞介素 6（IL-6）是一种多功能细胞因子，参与免疫调节、炎症、增加血管通透性、造血，并刺激细胞增殖等生物学过程。它主要通过经典和转信号通路发挥作用。许多研究表明，IL-6 在包括糖尿病视网膜病变、葡萄膜炎、年龄相关性黄斑变性、青光眼、视网膜静脉阻塞、中心性浆液性脉络膜视网膜病变和增生性玻璃体视网膜病变在内的多种视网膜疾病的发生发展中起着关键作用。因此，靶向 IL-6 和 IL-6 受体的药物的不断发展可能在多种视网膜疾病的治疗中发挥作用。本文全面综述了 IL-6 在各种视网膜疾病发病机制中的生物学功能及其作用机制，并总结了靶向 IL-6 及其受体的药物，展望了其在视网膜疾病中的潜在应用，以期为视网膜疾病的治疗提供新的思路。
