Tu Xinzhi, Duan Chun, Lin Bingying, Li Kangfeng, Gao Jie, Yan Huaying, Wang Kejian, Zhao Zhao
Department of Obstetrics and Gynecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Clinical laboratory, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
BMC Pregnancy Childbirth. 2022 Apr 7;22(1):297. doi: 10.1186/s12884-022-04635-w.
Fetal growth restriction (FGR) in utero leads to failure of fetus to reach the genetically normal growth potential. Currently available means of treating FGR are limited. And it remains unknown how pregnant women who give birth to FGR fetus differ in gut microbiota composition from normal pregnant women.
In this case-control study, fecal samples were obtained from maternal rectum in the operation room by an obstetrician under strict aseptic conditions. We compared gut microbiota of 14 pregnant women with FGR and 18 normal controls by performing 16S rDNA amplicon sequencing.
We identified significant differences in β-diversity between the FGR and control groups (P < 0.05). At genus level, Bacteroides, Faecalibacterium and Lachnospira were highly abundant in the FGR subjects, which are significantly enriched in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to glycometabolism.
These findings demonstrated that the distinct composition of the gut microbiota between FGR and normal pregnant women could contribute to an improved understanding of the prevention and treatment of FGR.
子宫内胎儿生长受限（FGR）会导致胎儿无法达到基因正常的生长潜力。目前可用的治疗FGR的方法有限。而且，分娩出FGR胎儿的孕妇与正常孕妇的肠道微生物群组成有何不同仍不清楚。
在这项病例对照研究中，由产科医生在严格无菌条件下于手术室从产妇直肠获取粪便样本。我们通过进行16S rDNA扩增子测序比较了14例FGR孕妇和18例正常对照的肠道微生物群。
我们发现FGR组和对照组之间的β多样性存在显著差异（P < 0.05）。在属水平上，拟杆菌属、粪杆菌属和毛螺菌属在FGR受试者中高度丰富，它们在与糖代谢相关的京都基因与基因组百科全书（KEGG）途径中显著富集。
这些发现表明，FGR孕妇与正常孕妇肠道微生物群的不同组成有助于增进对FGR预防和治疗的理解。
