Johnson T L, Lloyd R V, Burney R E, Thompson N W
Cancer. 1987 Jan 1;59(1):107-12. doi: 10.1002/1097-0142(19870101)59:1<107::aid-cncr2820590123>3.0.co;2-u.
Twenty-three Hurthle cell neoplasms of the thyroid were analyzed immunohistochemically for thyroglobulin, carcinoembryonic antigen (CEA), and for immunoreactivity with a monoclonal antibody to p21 ras oncogene product. Both benign and malignant tumors defined by the presence or absence of invasion and metastasis stained positively for thyroglobulin. Most tumors expressed both CEA and p21 ras oncogene product. Clinicopathologic analysis showed that malignant tumors were larger, occurred in slightly older patients (mean age, 52.8 years), and had an almost equal sex distribution, whereas benign tumors were more common in women and occurred in younger patients (mean age, 44.7 years). These results indicate that both benign and malignant Hurthle cell thyroid tumors produce thyroglobulin and express both CEA and p21 ras oncogene product, whereas adjacent normal thyroid tissues showed weak to absent immunoreactivity for p21 ras oncogene product. Because there are no specific immunohistochemical markers to distinguish between benign and malignant Hurthle cell tumors, one needs to rely on traditional histologic features such as invasion and metastasis to distinguish between benign and malignant Hurthle cell neoplasms.
对23例甲状腺嗜酸性细胞肿瘤进行免疫组织化学分析，检测甲状腺球蛋白、癌胚抗原（CEA）以及与p21 ras癌基因产物单克隆抗体的免疫反应性。根据有无侵袭和转移界定的良性和恶性肿瘤对甲状腺球蛋白均呈阳性染色。大多数肿瘤同时表达CEA和p21 ras癌基因产物。临床病理分析显示，恶性肿瘤体积更大，发生于年龄稍大的患者（平均年龄52.8岁），且性别分布几乎相等，而良性肿瘤在女性中更常见，发生于年龄较小的患者（平均年龄44.7岁）。这些结果表明，良性和恶性甲状腺嗜酸性细胞肿瘤均产生甲状腺球蛋白并表达CEA和p21 ras癌基因产物，而相邻的正常甲状腺组织对p21 ras癌基因产物的免疫反应性较弱或无反应。由于没有区分良性和恶性甲状腺嗜酸性细胞肿瘤的特异性免疫组织化学标志物，因此需要依靠侵袭和转移等传统组织学特征来区分良性和恶性甲状腺嗜酸性细胞肿瘤。
