Agelli M, Wahl S M
Clin Exp Rheumatol. 1986 Oct-Dec;4(4):379-88.
Inflammation is frequently associated with changes in the surrounding connective tissue. Inflammatory mononuclear cells (MNC) produce biologically active molecules, cytokines (CK), which may regulate the growth and function of connective tissue fibroblasts. In this article, we review the characteristics of lymphocyte and monocyte CK which appear to be involved in regulating fibroblast recruitment, proliferation, and matrix synthesis. Whereas these MNC products are important in normal physiologic wound healing, an imbalance of these CK may lead to pathophysiologic fibrosis and/or destruction of connective tissue components. Clinical states associated with MNC-mediated connective tissue pathology include scleroderma, rheumatoid arthritis, diffuse pulmonary idiopathic fibrosis, sarcoidosis and atherosclerosis. Characterization of the molecular pathways linking inflammatory mononuclear cells and fibrosis may provide avenues for therapeutic intervention.
炎症常与周围结缔组织的变化相关。炎性单核细胞（MNC）产生生物活性分子——细胞因子（CK），其可能调节结缔组织成纤维细胞的生长和功能。在本文中，我们综述了淋巴细胞和单核细胞CK的特征，这些特征似乎参与调节成纤维细胞的募集、增殖和基质合成。虽然这些MNC产物在正常生理伤口愈合中很重要，但这些CK的失衡可能导致病理生理性纤维化和/或结缔组织成分的破坏。与MNC介导的结缔组织病理相关的临床状态包括硬皮病、类风湿性关节炎、弥漫性肺特发性纤维化、结节病和动脉粥样硬化。阐明连接炎性单核细胞和纤维化的分子途径的特征可能为治疗干预提供途径。
