Cunliffe I A, Richardson P S, Rees R C, Rennie I G
Department of Ophthalmology and Orthoptics, University of Sheffield.
Br J Ophthalmol. 1995 Jun;79(6):590-5. doi: 10.1136/bjo.79.6.590.
Trabeculectomy is a commonly performed procedure for primary open angle glaucoma and is successful in the majority of cases. However, certain factors including aphakia, previous surgery, secondary glaucomas, ethnic origin, and the long term use of topical antiglaucoma medications may be associated with a reduced success rate. The mechanism (or mechanisms) which influence clinical outcome following trabeculectomy remain elusive. Alterations in the composition of the conjunctiva or aqueous humour may be partly responsible for this effect, and this could be mediated by cytokines. In this study we found that tumour necrosis factor (TNF), and interleukin 1 (IL-1) were capable of stimulating the proliferation of Tenon's capsule fibroblasts in tissue culture. Interleukin 6 (IL-6) did not appear to have any effect. The relevance of this to wound healing following trabeculectomy is discussed.
小梁切除术是原发性开角型青光眼的常见手术，大多数情况下手术成功。然而，某些因素，包括无晶状体眼、既往手术史、继发性青光眼、种族以及长期使用局部抗青光眼药物，可能与成功率降低有关。小梁切除术后影响临床结局的机制仍不清楚。结膜或房水成分的改变可能部分导致了这种情况，这可能由细胞因子介导。在本研究中，我们发现肿瘤坏死因子（TNF）和白细胞介素1（IL-1）能够在组织培养中刺激Tenon囊成纤维细胞的增殖。白细胞介素6（IL-6）似乎没有任何作用。本文讨论了这与小梁切除术后伤口愈合的相关性。
