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小鼠次级运动皮层第 5 层内脑细胞的皮质皮质神经支配亚型。

Corticocortical innervation subtypes of layer 5 intratelencephalic cells in the murine secondary motor cortex.

机构信息

National Institute for Physiological Sciences (NIPS), Okazaki 444-8787, Japan.

Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8787, Japan.

出版信息

Cereb Cortex. 2022 Dec 15;33(1):50-67. doi: 10.1093/cercor/bhac052.

DOI:10.1093/cercor/bhac052
PMID:35396593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9758586/
Abstract

Feedback projections from the secondary motor cortex (M2) to the primary motor and sensory cortices are essential for behavior selection and sensory perception. Intratelencephalic (IT) cells in layer 5 (L5) contribute feedback projections to diverse cortical areas. Here we show that L5 IT cells participating in feedback connections to layer 1 (L1) exhibit distinct projection patterns, genetic profiles, and electrophysiological properties relative to other L5 IT cells. An analysis of the MouseLight database found that L5 IT cells preferentially targeting L1 project broadly to more cortical regions, including the perirhinal and auditory cortices, and innervate a larger volume of striatum than the other L5 IT cells. We found experimentally that in upper L5 (L5a), ER81 (ETV1) was found more often in L1-preferring IT cells, and in IT cells projecting to perirhinal/auditory regions than those projecting to primary motor or somatosensory regions. The perirhinal region-projecting L5a IT cells were synaptically connected to each other and displayed lower input resistance than contra-M2 projecting IT cells including L1-preferring and nonpreferring cells. Our findings suggest that M2-L5a IT L1-preferring cells exhibit stronger ER81 expression and broader cortical/striatal projection fields than do cells that do not preferentially target L1.

摘要

来自次级运动皮层 (M2) 的反馈投射对于行为选择和感觉感知至关重要。第 5 层 (L5) 的内脑 (IT) 细胞对不同的皮质区域贡献反馈投射。在这里，我们表明，参与反馈连接到第 1 层 (L1) 的 L5 IT 细胞表现出与其他 L5 IT 细胞不同的投射模式、遗传特征和电生理特性。对 MouseLight 数据库的分析发现，L5 IT 细胞优先靶向 L1 的投射广泛到更多的皮质区域，包括旁嗅皮质和听觉皮质，并比其他 L5 IT 细胞更多地支配纹状体。我们通过实验发现，在上 L5 (L5a) 中，ER81 (ETV1) 在更倾向于投射到 L1 的 IT 细胞中更常被发现，并且在投射到旁嗅/听觉区域的 IT 细胞中比投射到主要运动或体感区域的 IT 细胞中更常被发现。投射到旁嗅区域的 L5a IT 细胞彼此之间存在突触连接，并且与包括 L1 倾向和非倾向细胞在内的投射到 contra-M2 的 IT 细胞相比，其输入电阻更低。我们的研究结果表明，与不优先靶向 L1 的细胞相比，M2-L5a IT L1 优先细胞表现出更强的 ER81 表达和更广泛的皮质/纹状体投射区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2c4/9758586/c0e318a0f9f6/bhac052f8.jpg
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