Valnes K, Myren J, Qvigstad T
Scand J Gastroenterol. 1978;13(4):497-500. doi: 10.3109/00365527809181928.
Forty patients with endoscopically confirmed gastric ulcers, completed a double-blind study comparing trimipramine with placebo during 4 weeks' treatment. The daily dose of trimipramine was 50 mg given before bedtime. No serious side-effects occurred. After four weeks' treatment 12 of the 20 patients receiving trimipramine had endoscopically completely healed ulcers, while in the placebo group only 4 of the 20 ulcers were healed (P = 0.025). With regard to the patients' complaints, a distinct and statistically significant improvement was also observed in the patients receiving trimipramine (P = 0.025). It is assumed that the previously shown antisecretory effect of the drug, together with the sedative and anti-depressive effect, make trimipramine a valuable drug in the treatment of peptic ulcer disease.
40例经内镜确诊为胃溃疡的患者完成了一项双盲研究，该研究比较了曲米帕明与安慰剂在4周治疗期间的效果。曲米帕明的每日剂量为50mg，睡前服用。未出现严重副作用。经过四周的治疗，接受曲米帕明治疗的20例患者中有12例经内镜检查溃疡完全愈合，而安慰剂组的20例溃疡中只有4例愈合（P = 0.025）。关于患者的主诉，接受曲米帕明治疗的患者也观察到明显且具有统计学意义的改善（P = 0.025）。据推测，该药物先前显示的抗分泌作用，以及镇静和抗抑郁作用，使曲米帕明成为治疗消化性溃疡疾病的一种有价值的药物。
