米安色林对五肽胃泌素刺激的和夜间胃分泌的抑制作用。
Inhibition of pentagastrin-stimulated and overnight gastric secretion by mianserin.
作者信息
Wilson J A, Read J R, Boyd E J, Wormsley K G
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 2(Suppl 2):329S-333S. doi: 10.1111/j.1365-2125.1983.tb05882.x.
1 The effects of mianserin (60 mg) have been studied on nocturnal and pentagastrin-stimulated gastric secretion. 2 Mianserin reduced pentagastrin-stimulated gastric acid secretion by 38%, pepsin by 40% and secretory volume by 45% during a 1 h test. 3 Twelve-hour overnight secretion of acid was reduced by 37%, while secretion of pepsin was reduced by 43% and secretory volume by 51%. 4 No adverse effects were noted. 5 These findings, which achieve statistical significance, suggest the need for further study to evaluate the possible role of mianserin in the therapy of duodenal ulcer disease.
已经研究了米安色林（60毫克）对夜间及五肽胃泌素刺激的胃酸分泌的影响。
在1小时的试验中，米安色林使五肽胃泌素刺激的胃酸分泌减少了38%，胃蛋白酶减少了40%，分泌量减少了45%。
夜间12小时的胃酸分泌减少了37%，而胃蛋白酶分泌减少了43%，分泌量减少了51%。
未观察到不良反应。
这些具有统计学意义的发现表明，需要进一步研究以评估米安色林在十二指肠溃疡疾病治疗中的可能作用。
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