Murray W R, Laferla G, Cooper G, Archibald M
Gut. 1986 Nov;27(11):1387-9. doi: 10.1136/gut.27.11.1387.
Forty patients who were managed conservatively after haemorrhage from an endoscopically verified duodenal ulcer were randomised at discharge from hospital to enter a blind study of ranitidine therapy (150 mg bd) versus a placebo tablet. The patients were re-endoscoped after four weeks, ulcer status defined and the trial code broken revealing that five of 20 placebo patients had healed their duodenal ulcer compared with 16 of 20 ranitidine patients (p = 0.001). Lifestyle parameters of both groups improved during the study period but no directly related benefit in duodenal ulcer healing could be shown. We conclude that effective anti-ulcer therapy, such as ranitidine, is required to heal a duodenal ulcer which presents with haemorrhage.
40例经内镜证实为十二指肠溃疡出血后接受保守治疗的患者在出院时被随机分组，进入一项雷尼替丁治疗（150毫克，每日两次）与安慰剂片的双盲研究。四周后对患者进行再次内镜检查，确定溃疡状态，试验编码被破解后发现，20例安慰剂组患者中有5例十二指肠溃疡愈合，而20例雷尼替丁组患者中有16例愈合（p = 0.001）。在研究期间，两组的生活方式参数均有所改善，但未显示出与十二指肠溃疡愈合有直接相关的益处。我们得出结论，治愈出血性十二指肠溃疡需要有效的抗溃疡治疗，如雷尼替丁。
