Department of Molecular Genetics and Biotechnologies, V.I. Vernadsky Crimean Federal University, Simferopol, Crimea.
Department of DNA Technologies of Engineering Center, V.I. Vernadsky Crimean Federal University, Simferopol, Crimea.
Inflamm Res. 2022 Jun;71(5-6):521-536. doi: 10.1007/s00011-022-01567-1. Epub 2022 Apr 10.
The vaccination rate worldwide has reached enormous proportions, and it is likely that at least 75% of the world's population will be vaccinated. The controversy is that, while people aged 65 and older suffer a significantly higher mortality rate from COVID-19, plans are being made to vaccinate young people under the age of 20. Equally thorny is the question of vaccinating people who already have antibodies to SARS-CoV-2, as well as B and T memory cells, because they contracted and survived the virus. The possible consequences of large-scale vaccination are difficult to predict, when some people do not have access to the vaccine at all and others have already received 3 doses of the vaccine. SARS-CoV-2 will circulate through the human population forever and continue to mutate, as viruses do. Therefore, in the coming years, the need to develop and use effective vaccines and medicines for the prevention and treatment of COVID-19 will remain urgent in view of the high mortality rate from this disease. To date, three vaccine platforms have been most used: adenoviral vector, inactivated, and mRNA. There is some concern about the side effects that occur after vaccination. Whether modern anti-coronavirus vaccines can raise the safety threshold, only time will answer. It is obvious that the pandemic will end, but the virus will remain in the human population, leaving behind invaluable experience and tens of millions of victims. This article is based on search retrieves in research articles devoted to COVID-19 mainly published in 2020-2021 and examines the possible consequences of the worldwide vaccination against SARS-CoV-2 and suggests that, while anti-coronavirus vaccines will not magically transport humanity to a non-pandemic world, they may greatly reduce the number of victims of the pandemic and help us learn how to live with COVID-19.
全球疫苗接种率已达到巨大规模,全球至少有 75%的人口可能会接种疫苗。争议在于,虽然 65 岁及以上的人群因 COVID-19 而导致的死亡率明显更高,但计划正在制定中,要为 20 岁以下的年轻人接种疫苗。同样棘手的问题是,对于已经对 SARS-CoV-2 具有抗体以及 B 和 T 记忆细胞的人,是否要进行接种,因为他们已经感染并幸存于该病毒。当一些人根本无法获得疫苗,而另一些人已经接种了 3 剂疫苗时,大规模接种的可能后果难以预测。SARS-CoV-2 将永远在人类中传播并继续变异,因为病毒就是这样。因此,鉴于这种疾病的高死亡率,在未来几年,开发和使用针对 COVID-19 的预防和治疗的有效疫苗和药物的需求仍将紧迫。迄今为止,使用最多的疫苗平台有三种:腺病毒载体、灭活和 mRNA。人们对接种疫苗后出现的副作用有些担忧。现代抗冠状病毒疫苗是否可以提高安全阈值,只有时间会给出答案。显然,大流行将结束,但病毒将留在人类中,留下宝贵的经验和数千万的受害者。本文基于对主要发表于 2020-2021 年的有关 COVID-19 的研究文章的检索结果,探讨了全球范围内针对 SARS-CoV-2 的疫苗接种的可能后果,并认为,虽然抗冠状病毒疫苗不会神奇地将人类带入无大流行的世界,但它们可能会大大减少大流行的受害者人数,并帮助我们了解如何与 COVID-19 共存。