Cao Pei, Zhang Lei, Yang Yang, Wang Xiao-Dan, Liu Zhao-Ping, Li Jian-Wen, Wang Li-Yuan, Chung Sookja, Zhou Moqin, Deng Ke, Zhou Ping-Ping, Wu Ping-Gu
China National Center for Food Safety Risk Assessment, Beijing 100022, China.
Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Food Chem. 2022 Sep 1;387:132823. doi: 10.1016/j.foodchem.2022.132823. Epub 2022 Mar 26.
The current study analysed concentrations of furan and its derivatives in coffee products commercially available in China based on an improved headspace gas chromatography-mass spectrometry (HS-GC-MS) method and estimated health risks. A total of 101 samples of coffee products on the Chinese market was analysed. Furan (98%, ND-6569 μg/kg) and 2-methylfuran (100%, 2-29639 μg/kg) were the compounds with the highest concentrations and detection rates in coffee products. The mean dietary exposure of Chinese consumers to furan and the sum of furan, 2-methylfuran and 3-methylfuran in coffee products was 0.09 and 0.46 μg/kg bw/day, respectively. For the neoplastic effects of furan, the margin of exposure (MOE) was 14,556 for the mean dietary exposure of consumers. For the non-neoplastic effects of furan, MOEs were 711 and 139 for furan and the sum of furan, 2-methylfuran and 3-methylfuran, respectively. Overall, a health concern is indicated for coffee consumers with MOEs below 10000.
本研究基于改进的顶空气相色谱 - 质谱联用（HS - GC - MS）方法分析了中国市场上可买到的咖啡产品中呋喃及其衍生物的浓度，并评估了健康风险。共分析了中国市场上的101份咖啡产品样本。呋喃（98%，未检出 - 6569μg/kg）和2 - 甲基呋喃（100%，2 - 29639μg/kg）是咖啡产品中浓度和检出率最高的化合物。中国消费者通过饮食摄入呋喃以及咖啡产品中呋喃、2 - 甲基呋喃和3 - 甲基呋喃总量的平均值分别为0.09和0.46μg/kg体重/天。对于呋喃的致癌效应，消费者平均饮食摄入量的暴露边际（MOE）为14556。对于呋喃的非致癌效应，呋喃以及呋喃、2 - 甲基呋喃和3 - 甲基呋喃总量的MOE分别为711和139。总体而言，MOE低于10000表明咖啡消费者存在健康问题。
