Mbida H, Tsala D E, Aboubakar S, Habtemariam S, Edmond J J, Bakwo E F, Minkande J Z
Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon.
Institute of Agricultural Research for Development, P.O. Box 2067, Yaoundé, Cameroon.
Evid Based Complement Alternat Med. 2022 May 12;2022:5318117. doi: 10.1155/2022/5318117. eCollection 2022.
The aim of this work was to evaluate the antioxidant potential of .
Heart failure was induced in the frog's heart by continuous perfusion of hydrogen peroxide. Survival time and some heart tissue parameters of oxidative stress were recorded in the presence of aqueous extracts of the leaves and seeds of . Ascorbic acid was used as a reference drug.
HO-enriched Ringer's solution inhibited the negative inotropic and chronotropic effects of acetylcholine, indicating the desensibilization of muscarinic receptors due to HO-induced oxidative stress. These hearts had a relatively short survival time (14 minutes). In the presence of the aqueous extract of the leaves and seeds of (1.5 and 2.5 mg/mL), the time necessary to cause the cardiac arrest was extended to 35 and 37 minutes, respectively, versus 29 minutes for ascorbic acid and 14 minutes for HO. Furthermore, antioxidant parameters (MDA, SOD, and CAT) were significantly improved in plant extract-treated hearts, compared to peroxidized hearts.
Aqueous extract of the leaves and seeds of . can extend heart survival time through antioxidant mechanisms.
本研究旨在评估……的抗氧化潜力。
通过持续灌注过氧化氢诱导青蛙心脏发生心力衰竭。在……的叶和种子水提取物存在的情况下，记录存活时间和一些氧化应激的心脏组织参数。以抗坏血酸作为对照药物。
富含过氧化氢的林格氏液抑制了乙酰胆碱的负性肌力和负性变时作用，表明由于过氧化氢诱导的氧化应激导致毒蕈碱受体脱敏。这些心脏的存活时间相对较短（14分钟）。在……的叶和种子水提取物（1.5和2.5毫克/毫升）存在的情况下，导致心脏骤停所需的时间分别延长至35和37分钟，而抗坏血酸为29分钟，过氧化氢为14分钟。此外，与过氧化的心脏相比，经植物提取物处理的心脏中的抗氧化参数（丙二醛、超氧化物歧化酶和过氧化氢酶）有显著改善。
……的叶和种子水提取物可通过抗氧化机制延长心脏存活时间。
