Chen Xufei, Dai Xufen, Liu Yinghai, He Xirui, Gong Gu
Department of Anesthesiology, The General Hospital of the Western Theater Command, Chengdu, China.
Shaanxi Institute for Food and Drug Control, Xi'an, China.
Front Pharmacol. 2022 Mar 24;13:766581. doi: 10.3389/fphar.2022.766581. eCollection 2022.
is a medicinal and food plant, often eaten as a wild vegetable in ancient China, and has been widely used for decades to treat sore throats, tonsillitis, colds and headaches, bronchitis, chronic hepatitis, joint rheumatism, snake and insect bites, and various cancers. This comprehensive and systematic review of the ethnomedicinal uses, phytochemical composition, pharmacological activity, quality control and toxicology of provides updated information for the further development and application in the fields of functional foods and new drugs research. To date, a total of 324 substances have been isolated and identified from the plant, including terpenoids, flavonoids, polyphenols, alkaloids, amino acids, and volatile oils. Among these substances, diterpenoids are the most important and abundant bioactive components. In the past decades pharmacological studies have shown that has significant biological activities, especially in the modulation of antitumor and multidrug resistance. However, most of these studies have been conducted . In-depth studies on the quality control of its crude extracts and active ingredients, as well as on metabolite identification are still very limited. Therefore, more well-designed preclinical and clinical studies are needed to confirm the reported therapeutic potential of .
是一种药食两用植物，在中国古代常作为野菜食用，数十年来一直被广泛用于治疗喉咙痛、扁桃体炎、感冒和头痛、支气管炎、慢性肝炎、关节风湿、蛇虫叮咬以及各种癌症。对该植物的民族药用用途、植物化学成分、药理活性、质量控制和毒理学进行的全面系统综述，为其在功能食品和新药研究领域的进一步开发和应用提供了最新信息。迄今为止，已从该植物中分离并鉴定出总共324种物质，包括萜类化合物、黄酮类化合物、多酚类化合物、生物碱、氨基酸和挥发油。在这些物质中，二萜类化合物是最重要且含量丰富的生物活性成分。在过去几十年中，药理学研究表明该植物具有显著的生物活性，尤其是在调节抗肿瘤和多药耐药性方面。然而，这些研究大多是……对其粗提物和活性成分的质量控制以及代谢物鉴定的深入研究仍然非常有限。因此，需要更多设计良好的临床前和临床研究来证实该植物已报道的治疗潜力。
