来自[具体来源未给出]的二萜类化合物及其一氧化氮生成抑制活性。
Diterpenoids from and their nitric oxide production inhibitory activity.
作者信息
Wen Chumao, Chen Su, Yuan Fang, Liu Xiangming, Song Fajun, Mei Zhinan, Yang Xiaofei, Yang Guangzhong
机构信息
College of Biomedical Engineering, South-Central University for Nationalities Wuhan 430074 P. R. China
College of Life Science, South Central University for Nationalities Wuhan 430074 P. R. China.
出版信息
RSC Adv. 2019 Dec 9;9(69):40628-40635. doi: 10.1039/c9ra08831h. eCollection 2019 Dec 3.
Six new -kaurane diterpenoids, isodonrubescins A-F (1-6), together with twenty-five known -kaurane diterpenoids (7-31), a known -atisane diterpenoid (32), and two known -abietane diterpenoids (33-34), were isolated from . Their structures were established by means of extensive MS and NMR data analysis. Among the all isolates, compound 7 was found in a natural product for the first time, and -atisane diterpenoid was discovered from in Hubei Province, P. R. China for the first time. Furthermore, all the isolated compounds were tested for their NO production inhibitory activity in LPS stimulated RAW264.7 cells. Compounds 7-9, 12, 13, 16, and 17 displayed NO production inhibitory activities with IC values ranging from 1.36 to 18.25 μM, respectively.
从……中分离出6个新的贝壳杉烷二萜类化合物，冬凌草红素A - F（1 - 6），以及25个已知的贝壳杉烷二萜类化合物（7 - 31）、1个已知的乌苏烷二萜类化合物（32）和2个已知的枞酸型二萜类化合物（33 - 34）。通过广泛的质谱和核磁共振数据分析确定了它们的结构。在所有分离物中，化合物7首次在天然产物中被发现，乌苏烷二萜类化合物首次在中国湖北省的……中被发现。此外，对所有分离得到的化合物进行了在脂多糖刺激的RAW264.7细胞中抑制一氧化氮产生活性的测试。化合物7 - 9、12、13、16和17表现出抑制一氧化氮产生的活性，其半数抑制浓度值分别在1.36至18.25μM范围内。
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