Eren Fettah, Ozguncu Cihat, Ozturk Serefnur
School of Medicine, Selcuk University, Konya, Turkey.
Front Neurol. 2022 Mar 24;13:812647. doi: 10.3389/fneur.2022.812647. eCollection 2022.
Stroke is a disease with high mortality and morbidity. Although studies are generally performed on all patients with stroke, it is known that gender has an effect on etiology and prognosis. This study aimed to determine the importance of clinical stroke scales and laboratory markers in determining the short-term prognosis of female patients with ischemic stroke of anterior circulation.
The study was planned as a retrospective and cross-sectional study. SEDAN score, the National Institutes of Health stroke scale (NIHSS), the Modified Rankin Scale (mRS), the Glasgow Coma Scale (GCS), and THRIVE score applied to the patients at the time of admission were recorded. Admission blood glucose, hemoglobin, leukocyte, urea, albumin, and blood lipid levels were evaluated. The relationship of all these parameters with in-hospital prognosis, mortality, and disability at discharge was examined. The relationship between groups and data was analyzed using the SPSS package program after the normality analysis.
In this study, there were 733 female patients with stroke with a mean age of 69.53 ± 14.51 years and 858 male patients with stroke with a mean age of 64.27 ± 13.29 years. Hospitalization time, length of stay in the intensive care unit, ventilation need rate, mortality, and dependency rate were higher in female patients ( = 0.001). The NIHSS, SEDAN, and THRIVE scores were higher in female patients who had in-hospital mortality, had a poor prognosis, and who were discharged as dependent ( = 0.001). GCS was lower in this patient group ( = 0.001). Blood glucose, creatinine, leukocytes, urea, and CRP levels were higher; the albumin and hemoglobin levels was lower in female patients who had fatal outcomes ( = 0.009, 0.001, 0.001, 0.001, 0.001, and 0.020; respectively). In female patients who were dependent at discharge, blood urea, glucose, and CRP levels were higher and the albumin levels were lower than those in female patients who achieved functional independence ( = 0.001, 0.016, 0.002, and 0.001, respectively).
Our study showed that the short-term prognosis is worse in female patients who had an ischemic stroke of anterior circulation. It also revealed some clinical and laboratory parameters that could predict this situation. More intensive monitoring may be needed to improve prognosis in female patients.
中风是一种死亡率和发病率都很高的疾病。尽管研究通常是针对所有中风患者进行的，但已知性别会对病因和预后产生影响。本研究旨在确定临床中风量表和实验室指标在评估前循环缺血性中风女性患者短期预后方面的重要性。
本研究计划为一项回顾性横断面研究。记录患者入院时应用的SEDAN评分、美国国立卫生研究院卒中量表（NIHSS）、改良Rankin量表（mRS）、格拉斯哥昏迷量表（GCS）和THRIVE评分。评估入院时的血糖、血红蛋白、白细胞、尿素、白蛋白和血脂水平。检查所有这些参数与住院预后、死亡率和出院时残疾情况之间的关系。在进行正态性分析后，使用SPSS软件包程序分析组间和数据之间的关系。
在本研究中，有733例中风女性患者，平均年龄为69.53±14.51岁，858例中风男性患者，平均年龄为64.27±13.29岁。女性患者的住院时间、重症监护病房停留时间、通气需求率、死亡率和依赖率更高（P = 0.001）。住院死亡、预后不良且出院时依赖的女性患者的NIHSS、SEDAN和THRIVE评分更高（P = 0.001）。该患者组的GCS更低（P = 0.001）。有致命结局的女性患者血糖、肌酐、白细胞、尿素和CRP水平更高；白蛋白和血红蛋白水平更低（分别为P = 0.009、0.001、0.001、0.001、0.001和0.020）。出院时依赖的女性患者血尿素、血糖和CRP水平更高，白蛋白水平低于实现功能独立的女性患者（分别为P = 0.001、0.016、0.002和0.001）。
我们的研究表明，前循环缺血性中风女性患者的短期预后更差。研究还揭示了一些可以预测这种情况的临床和实验室参数。可能需要更密切的监测以改善女性患者的预后。
