一天中膳食维生素摄入时间与心血管疾病及全因死亡率的关联
The Association of Dietary Vitamin Intake Time Across a Day With Cardiovascular Disease and All-Cause Mortality.
作者信息
Gu Wenbo, Wu Huanyu, Hu Cong, Xu Jiaxu, Jiang Hongyan, Long Yujia, Han Tianshu, Yang Xue, Wei Wei, Jiang Wenbo
机构信息
The National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
出版信息
Front Cardiovasc Med. 2022 Mar 23;9:822209. doi: 10.3389/fcvm.2022.822209. eCollection 2022.
BACKGROUND
Chrono-nutrition emphasized the importance of the intake time; however, less is known about the impact of dietary vitamin intake time on health. This study aimed to examine our hypothesis about which vitamin intake time could influence the natural course of cardiovascular disease (CVD).
METHODS
A total of 27,455 adults enrolled in the National Health and Nutrition Examination Survey (NHANES) during 2003-2014 were recruited. The 12 dietary vitamin intakes in the morning, afternoon, and evening were categorized into tertiles or quartiles. Cox-proportional hazard regression models were developed to evaluate the association of vitamin intake time with CVD and all-cause mortalities.
RESULTS
Compared with participants in the lowest quartile, participants in the highest quartile of dietary VB2 intake in the morning had significantly lowest mortality risk of CVD [hazard ratio (HR) = 0.75, 95% CI: 0.60-0.94, = 0.017]; whereas, participants in the highest quartile of dietary-vitamin B6 (VB6), vitamin C (VC), vitamin E (VE), and folate-equivalent consumed in the evening showed the lowest risks of CVD (HR = 0.77, 95% CI: 0.60-0.99, = 0.103; HR = 0.80, 95% CI: 0.65-0.98, = 0.050; HR = 0.75, 95% CI: 0.56-0.99, = 0.032; HR = 0.78, 95% CI: 0.63-0.97, = 0.116) and all-cause mortalities (HR = 0.81, 95% CI: 0.71-0.93, = 0.006; HR = 0.85, 95% CI: 0.76-0.95, = 0.004; HR = 0.84, 95% CI: 0.72-0.97, = 0.011; HR = 0.80, 95% CI: 0.71-0.90, = 0.001). Moreover, equivalently replacing 10% intake of dietary VB6, VC, VE, and folate-equivalent in the morning with evening were associated with 4% (HR = 0.96, 95% CI: 0.92-0.99), 5% (HR = 0.95, 95% CI: 0.92-0.99), 4% (HR = 0.96, 95% CI: 0.91-0.99), and 5% (HR = 0.95, 95% CI: 0.92-0.99) lower risk of CVD mortality.
CONCLUSION
This study found that the optimal intake time of dietary VB2 was in the morning, and the optimal intake times of dietary VB6, VC, VE, and folate-equivalent were in the evening.
背景
时间营养学强调了摄入时间的重要性；然而，关于膳食维生素摄入时间对健康的影响却知之甚少。本研究旨在检验我们关于哪种维生素摄入时间会影响心血管疾病（CVD）自然病程的假设。
方法
招募了2003年至2014年期间参加美国国家健康与营养检查调查（NHANES）的27455名成年人。将上午、下午和晚上的12种膳食维生素摄入量分为三分位数或四分位数。建立Cox比例风险回归模型以评估维生素摄入时间与CVD及全因死亡率之间的关联。
结果
与摄入量处于最低四分位数的参与者相比，上午膳食维生素B2摄入量处于最高四分位数的参与者CVD死亡风险显著最低[风险比（HR）=0.75，95%置信区间（CI）：0.60 - 0.94，P = 0.017]；然而，晚上摄入膳食维生素B6（VB））、维生素C（VC）、维生素E（VE）和叶酸当量处于最高四分位数的参与者CVD风险最低（HR = 0.77，95% CI：0.60 - 0.99，P = 0.103；HR = 0.80，95% CI：0.65 - 0.98，P = 0.050；HR = 0.75，95% CI：0.56 - 0.99，P = 0.032；HR = 0.78，95% CI：0.63 - 0.９７，P = 0.116）以及全因死亡率最低（HR = 0.81，95% CI：0.71 - 0.93，P = 0.006；HR = 0.85，95% CI：0.76 - 0.95，P = 0.004；HR = 0.84，95% CI：0.72 - 0.97，P = 0.011；HR = 0.80，95% CI：0.71 - 0.90，P = 0.001）。此外，将上午膳食VB6、VC、VE和叶酸当量摄入量的10%等量替换为晚上摄入，与CVD死亡率风险分别降低4%（HR = 0.96，95% CI：0.92 - 0.99）、5%（HR = 0.95，95% CI：0.92 - 0.99）、4%（HR = 0.96, 95% CI：0.91 - 0.99）和5%（HR = 0.95，95% CI：0.92 - 0.99）相关。
结论
本研究发现，膳食VB2的最佳摄入时间是上午，膳食VB6、VC、VE和叶酸当量的最佳摄入时间是晚上。
Zotero 插件