Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Trends Endocrinol Metab. 2019 Oct;30(10):767-779. doi: 10.1016/j.tem.2019.07.008. Epub 2019 Aug 16.
The circadian system, that is ubiquitous across species, generates ∼24 h rhythms in virtually all biological processes, and allows them to anticipate and adapt to the 24 h day/night cycle, thus ensuring optimal physiological function. Epidemiological studies show time-of-day variations in adverse cardiovascular (CV) events, and controlled laboratory studies demonstrate a circadian influence on key markers of CV function and risk. Furthermore, circadian misalignment, that is typically experienced by shift workers as well as by individuals who experience late eating, (social) jet lag, or circadian rhythm sleep-wake disturbances, increases CV risk factors. Therefore, understanding the mechanisms by which the circadian system regulates CV function, and which of these are affected by circadian disruption, may help to develop intervention strategies to mitigate CV risk.
昼夜节律系统在几乎所有生物过程中产生约 24 小时的节律，使它们能够预测和适应 24 小时的昼夜循环，从而确保最佳的生理功能。流行病学研究表明，心血管（CV）不良事件存在时间变化，而对照实验室研究表明，CV 功能和风险的关键标志物受到昼夜节律的影响。此外，昼夜节律失调通常发生在轮班工人以及饮食时间晚、（社交）时差、或昼夜节律睡眠-觉醒障碍的个体中，增加了心血管危险因素。因此，了解昼夜节律系统调节心血管功能的机制，以及哪些机制受到昼夜节律紊乱的影响，可能有助于制定干预策略来降低心血管风险。
