Garcinuño Sara, Aranaz Inmaculada, Civera Concepción, Arias Concepción, Acosta Niuris
Pluridisciplinar Institute, Complutense University, 28040 Madrid, Spain.
Department of Chemistry in Pharmaceutical Science, Pharmacy Faculty, Complutense University, 28040 Madrid, Spain.
Polymers (Basel). 2022 Mar 26;14(7):1355. doi: 10.3390/polym14071355.
In this work, two chitosan samples from cuttlebone and squid pen are produced and characterized. We studied the formation of thermoresponsive hydrogels with β-glycerol phosphate and found proper formulations that form the hydrogels at 37 °C. Gel formation depended on the chitosan source being possible to produce the thermoresponsive hydrogels at chitosan concentration of 1% with cuttlebone chitosan but 1.5% was needed for squid pen. For the first time, these non-commercial chitosan sources have been used in combination with β-glycerol phosphate to prepare risperidone formulations for controlled drug delivery. Three types of formulations for risperidone-controlled release have been developed, in-situ gelling formulations, hydrogels and xerogels. The release profiles show that in-situ gelling formulations and particularly hydrogels allow an extended control release of risperidone while xerogels are not appropriate formulations for this end since risperidone was completely released in 48 h.
在这项工作中，制备并表征了来自乌贼骨和鱿鱼笔的两种壳聚糖样品。我们研究了用β-甘油磷酸酯形成热响应性水凝胶的过程，并找到了在37℃下形成水凝胶的合适配方。凝胶的形成取决于壳聚糖的来源，乌贼骨壳聚糖在壳聚糖浓度为1%时可制备热响应性水凝胶，但鱿鱼笔壳聚糖则需要1.5%。首次将这些非商业壳聚糖来源与β-甘油磷酸酯结合用于制备用于控释药物的利培酮制剂。已开发出三种类型的利培酮控释制剂，即原位凝胶制剂、水凝胶和干凝胶。释放曲线表明，原位凝胶制剂尤其是水凝胶能够实现利培酮的延长控释，而干凝胶不是实现此目的的合适制剂，因为利培酮在48小时内完全释放。
