Taucher Elisabeth, Mykoliuk Iurii, Fediuk Melanie, Smolle-Juettner Freyja-Maria
Division of Pulmonology, Department of Internal Medicine, Medical University Graz, 8036 Graz, Austria.
Division of Thoracic Surgery, Department of Surgery, Medical University Graz, 8036 Graz, Austria.
Cancers (Basel). 2022 Mar 23;14(7):1637. doi: 10.3390/cancers14071637.
Autophagy is an important cellular repair mechanism, aiming at sequestering misfolded and dysfunctional proteins and damaged cell organelles. Dysfunctions in the autophagy process have been linked to several diseases, like infectious and neurodegenerative diseases, type II diabetes mellitus and cancer. Living organisms are constantly subjected to some degree of oxidative stress, mainly induced by reactive oxygen and nitrogen species. It has been shown that autophagy is readily induced by reactive oxygen species (ROS) upon nutrient deprivation. In recent years, research has increasingly focused on outlining novel therapeutic targets related to the autophagy process. With this review of the literature, we want to give an overview about the link between autophagy, oxidative stress and carcinogenesis.
自噬是一种重要的细胞修复机制，旨在隔离错误折叠和功能失调的蛋白质以及受损的细胞器。自噬过程中的功能障碍与多种疾病有关，如感染性疾病、神经退行性疾病、II型糖尿病和癌症。生物体经常受到一定程度的氧化应激，主要由活性氧和氮物种诱导产生。研究表明，在营养缺乏时，活性氧（ROS）很容易诱导自噬。近年来，研究越来越集中在勾勒与自噬过程相关的新治疗靶点。通过对文献的综述，我们希望概述自噬、氧化应激与致癌作用之间的联系。
