Giri A K
Mutat Res. 1986 Nov;168(3):241-8. doi: 10.1016/0165-1110(86)90022-9.
2,3,7,8-Tetrachlorodibenzo-p-dioxin is one of the most toxic and highly stable compounds known in the environment. Due to uncontrolled exothermic reactions during manufacture of 2,4,5-T and other chlorophenoxy compounds, TCDD is released in the environment. The importance of determining the hazards to human health from dioxin became apparent because of its severe adverse health effects. 'Agent Orange' which is a mixture of 2,4,5-T and 2,4-D has been extensively used during the late Vietnam War. In this review an attempt has been made to evaluate the mutagenic and genotoxic effects of 2,3,7,8-TCDD as known at present.
2,3,7,8-四氯二苯并-对-二噁英是环境中已知的毒性最强且高度稳定的化合物之一。在2,4,5-涕及其他氯苯氧基化合物的制造过程中，由于无法控制的放热反应，二噁英被释放到环境中。由于二噁英对健康有严重的不良影响，确定其对人类健康危害的重要性变得显而易见。“橙剂”是2,4,5-涕和2,4-滴的混合物，在越南战争后期被广泛使用。在这篇综述中，已尝试评估目前已知的2,3,7,8-四氯二苯并-对-二噁英的诱变和遗传毒性作用。
