Phytochemical Study of F. Delaroche and the Inhibitory Capacity of Its Main Compounds on Two Glucose-Producing Pathway Enzymes.

One undescribed acylated flavonol glucoside and five known compounds were isolated from the aerial parts of F. Delaroche, a plant that is used in traditional Mexican medicine to treat type 2 diabetes. The chemical structures of the isolated compounds were elucidated using a variety of spectroscopic techniques, including 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS). Chlorogenic acid (), rosmarinic acid (), caffeic acid (), protocatechuic acid (), kaempferol-3--(2,6-----coumaryl)--d-glucopyranoside (), and the new acylated flavonol glucoside quercetin-3--(2,6-----coumaryl)--d-glucopyranoside () were isolated. This is the first report on the natural occurrence of quercetin-3--(2,6-----coumaryl)--D-glucopyranoside (). In addition, according to the HPLC profile obtained for the water extract (WE), chlorogenic acid () and rosmarinic acid () were identified as the main compounds, while kaempferol-3--(2,6-----coumaryl)--d-glucopyranoside () were the main compound in the butanolic extract. We demonstrate the important role of compound over the inhibition of G6Pase and FBPase. The isolated compounds may play an important role in the hypoglycemic effect of the extract and may act in a synergic way, but more experiments are needed to corroborate these findings.