Jeon Soo Ji, Jung Kyoung In, Park Chan Kee, Park Hae-Young Lopilly
Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon 14647, Korea.
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
J Clin Med. 2022 Mar 24;11(7):1790. doi: 10.3390/jcm11071790.
To investigate whether macular vessel density (VD) was associated with the pattern electroretinogram (PERG) in normal tension glaucoma (NTG).
Cross-sectional study.
Seventy-six eyes from patients with NTG were included in this study. Macular VD was calculated from the superficial retinal layer, including the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), using the built-in software provided with the optical coherence tomography angiography (OCTA) device. Functional parameters were obtained from standard automated perimetry (SAP) and PERG, using a commercial ERG stimulator. Moreover, structural parameters, such as peripapillary RNFL and macular ganglion cell/inner plexiform layer (GCIPL) thickness, were measured using OCT.
Patients with higher VD had higher N95 amplitude ( = 0.048). Macular VD was significantly correlated with N95 amplitude, irrespective of disease severity (r = 0.352, = 0.002 for the total subjects and r = 0.276, = 0.043 for mild glaucoma). According to regression analyses, N95 amplitude and macular VD were bidirectional significant factors ( = 0.035 and 0.019, respectively). For patients with mild to moderate glaucoma, N95 amplitude and macular VD were also significantly associated bidirectionally, according to regression analyses ( = 0.032 and 0.040, respectively).
Macular VD was significantly associated with N95 amplitude from PERG. The correlation was prominent in early glaucoma, in contrast to the other structural or functional parameters. When considering that PERG represents the objective function of the retinal ganglion cell (RGC), macular VD was associated with RGC dysfunction before the functional change became apparent on SAP.
研究正常眼压性青光眼（NTG）患者的黄斑血管密度（VD）与图形视网膜电图（PERG）是否相关。
横断面研究。
本研究纳入了76例NTG患者的眼睛。使用光学相干断层扫描血管造影（OCTA）设备附带的内置软件，从包括视网膜神经纤维层（RNFL）和神经节细胞层（GCL）的视网膜浅层计算黄斑VD。使用商用视网膜电图刺激器，从标准自动视野计（SAP）和PERG获得功能参数。此外，使用OCT测量视乳头周围RNFL和黄斑神经节细胞/内丛状层（GCIPL）厚度等结构参数。
VD较高的患者N95波幅较高（P = 0.048）。无论疾病严重程度如何，黄斑VD与N95波幅均显著相关（所有受试者r = 0.352，P = 0.002；轻度青光眼患者r = 0.276，P = 0.043）。根据回归分析，N95波幅和黄斑VD是双向显著因素（分别为P = 0.035和0.019）。对于轻度至中度青光眼患者，根据回归分析，N95波幅和黄斑VD也存在显著的双向关联（分别为P = 0.032和0.040）。
黄斑VD与PERG的N95波幅显著相关。与其他结构或功能参数相比，这种相关性在早期青光眼患者中更为突出。考虑到PERG代表视网膜神经节细胞（RGC）的客观功能，在SAP上功能变化明显之前，黄斑VD就与RGC功能障碍相关。
