de Oliveira Larissa Medeiros, Matos Robert Saraiva, Ţălu Ştefan, Rocha Ana Luisa Farias, de Aguiar Nunes Ronald Zico, Bezerra Jaqueline de Araújo, Campelo Felix Pedro Henrique, Inada Natália Mayumi, Sanches Edgar Aparecido, da Fonseca Filho Henrique Duarte
Laboratory of Nanostructured Polymers (NANOPOL-@nanopol_ufam), Department of Physics, Federal University of Amazonas (UFAM), Manaus 69067-005, AM, Brazil.
Amazonian Materials Group, Department of Physics, Federal University of Amapá (UNIFAP), Macapá 68903-419, AP, Brazil.
Materials (Basel). 2022 Apr 3;15(7):2635. doi: 10.3390/ma15072635.
Biodegradable particles were developed using poly-ε-caprolactone and gelatin carriers containing different concentrations of essential oil (EO) (360 µg/mL, 420 µg/mL, and 460 µg/mL). Atomic force microscopy was useful to evaluate the particles' surface based on morphological parameters. The particles' size varied from 150 nm to 300 nm. The diameter was related to the increase of the particles' height as a function of the EO concentration, influencing the roughness of the surface core values (from 20 to 30 nm) and surface irregularity. The spatial parameters Str (texture aspect ratio) and Std (texture direction) revealed low spatial frequency components. The hybrid parameters Sdq (root mean square gradient) and Sdr (interfacial area ratio) also increased as a function of the EO concentration, revealing fewer flat particles. On the other hand, the functional parameters (inverse areal material ratio and peak extreme height) suggested differences in surface irregularities. Higher concentrations of EO resulted in greater microtexture asperity on the particles' surface, as well as sharper peaks. The nanoscale morphological surface analysis allowed the determination of the most appropriate concentration of encapsulated EO, influencing statistical surface parameters.
使用聚己内酯和含有不同浓度精油（EO）（360 µg/mL、420 µg/mL和460 µg/mL）的明胶载体开发了可生物降解颗粒。原子力显微镜有助于根据形态学参数评估颗粒表面。颗粒尺寸在150纳米至300纳米之间变化。直径与颗粒高度随EO浓度的增加有关，影响表面核心值（从20至30纳米）的粗糙度和表面不规则性。空间参数Str（纹理长宽比）和Std（纹理方向）显示出低空间频率分量。混合参数Sdq（均方根梯度）和Sdr（界面面积比）也随EO浓度的增加而增加，表明扁平颗粒较少。另一方面，功能参数（反面积材料比和峰极值高度）表明表面不规则性存在差异。较高浓度的EO导致颗粒表面的微观纹理粗糙度更大，峰更尖锐。纳米级形态表面分析能够确定包封EO的最合适浓度，影响统计表面参数。
