Analysis of the Composition of Snake Venom Based on Proteomics, and Its Antithrombotic Activity and Toxicity Studies.

There is a strong correlation between the composition of venom proteins and their potential pharmacological effects. The proteomic analysis revealed 103 proteins identified through label-free proteomics from 30 different snake venom families. Phospholipase A2 (30.0%), snaclec (21.0%), antithrombin (17.8%), thrombin (8.1%) and metalloproteinases (4.2%) were the most abundant proteins. The main toxicity of venom is hematotoxicity and neurotoxicity, and it acts on the lung. venom may have anticoagulant and antithrombotic effects. In summary, the protein profile and related toxicity and pharmacological activity of venom from southwest China were put forward for the first time. In addition, we revealed the relationship between the main toxicity, pharmacological effects, and the protein components of snake venom.