Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 02000 Kyiv, Ukraine.
Int J Mol Sci. 2022 Apr 3;23(7):3996. doi: 10.3390/ijms23073996.
Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient's response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes.
循环 microRNAs（c-microRNAs，c-miRNAs）存在于几乎所有生物体液中，是各种疾病（肿瘤和心血管疾病、神经退行性病变等）有前途的敏感生物标志物，其特征准确反映了身体的状态。microRNA 标志物表达的研究表明，它们可以在临床症状出现之前广泛诊断各种疾病，并可以帮助评估患者对治疗的反应，以纠正和个性化治疗。本综述讨论了 miRNA 在诊断和治疗各种疾病（病毒和非病毒）中的最新应用趋势。结论是，外源性 microRNAs 可用于这些目的的高精度治疗剂。
