Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168 Rome, Italy.
Department of Geriatrics, Neurosciences, Orthopaedics and Head and Neck, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.
Int J Environ Res Public Health. 2022 Apr 2;19(7):4279. doi: 10.3390/ijerph19074279.
To assess the event rates of myocarditis detected by Cardiac Magnetic Resonance (CMR) in athletes who recovered from COVID-19.
A systematic literature search was performed to identify studies reporting abnormal CMR findings in athletes who recovered from COVID-19. Secondary analyses were performed considering increased serum high sensitivity troponin (hs-Tn) levels and electrocardiographic (ECG) and echocardiographic (ECHO) abnormalities.
In total, 7988 athletes from 15 studies were included in the analysis. The pooled event rate of myocarditis was 1% (CI 1-2%), reaching 4% in the sub-group analysis. In addition, heterogeneity was observed (I2 43.8%). The pooled event rates of elevated serum hs-Tn levels, abnormal ECG and ECHO findings were 2% (CI 1-5%), 3% (CI 1-10%) and 2% (CI 1-6%), respectively. ECG, ECHO and serum hs-Tn level abnormalities did not show any correlation with myocarditis.
The prevalence of COVID-19-related myocarditis in the athletic population ranges from 1 to 4%. Even if the event rate is quite low, current screening protocols are helpful tools for a safe return to play to properly address CMR studies.
the study protocol was registered in the PROSPERO database (registration number: CRD42022300819).
评估 COVID-19 康复运动员中心脏磁共振（CMR）检测到的心肌炎发生率。
进行了系统的文献检索，以确定报告 COVID-19 康复运动员异常 CMR 结果的研究。进行了二次分析，考虑了血清高敏肌钙蛋白（hs-Tn）水平升高以及心电图（ECG）和超声心动图（ECHO）异常。
共纳入来自 15 项研究的 7988 名运动员进行分析。心肌炎的总发生率为 1%（95%CI 1-2%），亚组分析中为 4%。此外，观察到异质性（I2 43.8%）。血清 hs-Tn 水平升高、ECG 和 ECHO 异常的总发生率分别为 2%（95%CI 1-5%）、3%（95%CI 1-10%）和 2%（95%CI 1-6%）。ECG、ECHO 和血清 hs-Tn 水平异常与心肌炎之间无相关性。
在运动员人群中，COVID-19 相关心肌炎的患病率为 1%至 4%。即使发生率相当低，但目前的筛查方案是有助于安全重返运动的有用工具，可以正确进行 CMR 研究。
该研究方案已在 PROSPERO 数据库中注册（注册号：CRD42022300819）。
