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非 90 岁及以上和 100 岁及以上患者粗隆间骨折后病死率的发生率及危险因素:2 年随访。

Incidence and Risk Factors of Mortality in Nonagenarians and Centenarians After Intertrochanteric Fracture: 2-Year Follow-Up.

机构信息

Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.

Orthopaedic Research Institute of Hebei Province, Shijiazhuang, Hebei, People's Republic of China.

出版信息

Clin Interv Aging. 2022 Apr 5;17:369-381. doi: 10.2147/CIA.S360037. eCollection 2022.

Abstract

PURPOSE

The purpose of this study was to explore risk factors for mortality after intertrochanteric fracture (IF) surgery in nonagenarians and centenarians based on subgroups of follow-up time.

PATIENTS AND METHODS

A total of 144 nonagenarians and centenarians who underwent IF surgery between Jan. 2014 and Dec. 2018 were included. Data were compared between the mortality and the survival groups based on the subgroups of follow-up time in univariate, logistic regression, and Cox regression analyses.

RESULTS

In our study, the rates of mortality were 7.6%, 13.9%, and 28.5% at 6-month, 1-year, and 2-year follow-up, respectively. Univariate analysis showed that prolonged time from injury to surgery, more transfusion volume, lower hemoglobin (minimum), and complications (respiratory failure and anemia) were associated with mortality at 6-month follow-up. However, three factors were found to be related to mortality at 1-year and 2-year follow-up, respectively. Our results showed that postoperative respiratory failure and anemia were independent risk factors for mortality after IF surgery at 6-month in logistic regression analysis. However, postoperative respiratory failure was found as an independent risk factor for mortality at 1-year and 2-year follow-up. Moreover, Cox regression analysis showed that postoperative respiratory failure was an independent risk factor for mortality after IF surgery, which was consistent with results in logistic regression analysis.

CONCLUSION

Postoperative respiratory failure was an independent risk factor for mortality in nonagenarians and centenarians at any follow-up. Additionally, postoperative anemia was closely related to mortality. Preoperative measures should be taken to lower mortality.

摘要

目的

本研究旨在探讨基于随访时间亚组的 90 岁及以上高龄患者股骨转子间骨折(IF)手术后死亡的危险因素。

方法

回顾性分析 2014 年 1 月至 2018 年 12 月期间接受 IF 手术的 144 例 90 岁及以上高龄患者的临床资料。根据随访时间的亚组,对死亡组和生存组进行单因素、logistic 回归和 Cox 回归分析。

结果

本研究中,6 个月、1 年和 2 年的死亡率分别为 7.6%、13.9%和 28.5%。单因素分析显示,受伤至手术时间延长、输血量增加、血红蛋白最低值降低以及并发症(呼吸衰竭和贫血)与 6 个月时的死亡率相关。然而,有 3 个因素与 1 年和 2 年的死亡率相关。logistic 回归分析显示,术后呼吸衰竭和贫血是 6 个月时 IF 手术后死亡的独立危险因素。然而,术后呼吸衰竭是 1 年和 2 年随访时死亡的独立危险因素。此外,Cox 回归分析显示,术后呼吸衰竭是 IF 手术后死亡的独立危险因素,与 logistic 回归分析结果一致。

结论

术后呼吸衰竭是 90 岁及以上高龄患者任何时间随访时死亡的独立危险因素。此外,术后贫血与死亡率密切相关。应采取术前措施降低死亡率。

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