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老年急性A型主动脉夹层患者有限修复与保守治疗方法的临床结局

Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection.

作者信息

Maze Yasumi, Tokui Toshiya, Murakami Masahiko, Nakamura Bun, Inoue Ryosai, Hirano Reina, Hirano Koji

机构信息

Department of Thoracic and Cardiovascular Surgery, Ise Red Cross Hospital, 1-471-2 Funae, Ise, Mie, 516-8512, Japan.

出版信息

J Cardiothorac Surg. 2022 Apr 15;17(1):78. doi: 10.1186/s13019-022-01819-5.

Abstract

BACKGROUND

Surgical indication and the selection of surgical procedures for acute type A aortic dissection in older patients are controversial; therefore, we aimed to examine the surgical outcomes of acute type A aortic dissection in older patients.

METHODS

From January 2012 through December 2019, 174 patients underwent surgical repair for acute type A aortic dissection. We compared the surgical outcomes between the older (≥ 80 years old) and below-80 (≤ 79 years old) age groups. Additionally, we compared the outcomes between the surgical and conservative treatment groups.

RESULTS

The primary entry was found in the ascending aorta in 51.6% and 32.8% of the older and below-80 groups, respectively (p = 0.049). Ascending or hemiarch replacement was performed in all older group patients and 57.3% of the below-80 group patients (total arch replacement was performed in the remaining 42.7%; p < 0.001). Hospital mortality rates were similar in both groups. The significant risk factors for hospital mortality were age, preoperative intubation, cardiopulmonary bypass time, and postoperative stroke. The 5-year survival rates were 48.4% ± 10.3% (older group) and 86.7% ± 2.9% (below-80 group; p < 0.001). The rates of freedom from aortic events at 5 years were 86.9% ± 8.7% (older group) and 86.5% ± 3.9% (below-80 group; p = 0.771). The 5-year survival rate of the conservative treatment subgroup was 19.2% ± 8.0% in the older group, which was not significantly different from that of the surgical treatment subgroup (p = 0.103).

CONCLUSION

The surgical approach did not achieve a significant survival advantage over conservative treatment and may not always be a reasonable treatment of choice for older patients.

摘要

背景

老年患者急性A型主动脉夹层的手术指征及手术方式选择存在争议;因此,我们旨在研究老年患者急性A型主动脉夹层的手术效果。

方法

2012年1月至2019年12月,174例患者接受了急性A型主动脉夹层的手术修复。我们比较了老年(≥80岁)和80岁以下(≤79岁)年龄组的手术效果。此外,我们还比较了手术治疗组和保守治疗组的效果。

结果

老年组和80岁以下组分别有51.6%和32.8%的患者原发破口位于升主动脉(p = 0.049)。老年组所有患者及80岁以下组57.3%的患者接受了升主动脉或半弓置换(其余42.7%接受了全弓置换;p < 0.001)。两组的住院死亡率相似。住院死亡的显著危险因素为年龄、术前插管、体外循环时间和术后卒中。5年生存率分别为48.4%±10.3%(老年组)和86.7%±2.9%(80岁以下组;p < 0.001)。5年无主动脉事件发生率分别为86.9%±8.7%(老年组)和86.5%±3.9%(80岁以下组;p = 0.771)。老年组保守治疗亚组的5年生存率为19.2%±8.0%,与手术治疗亚组无显著差异(p = 0.103)。

结论

手术治疗相对于保守治疗并未取得显著的生存优势,对于老年患者可能并非总是合理的治疗选择。

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