鼠伤寒沙门氏菌中果糖磷酸转移酶系统对糖异生作用调控的证据。
Evidence for regulation of gluconeogenesis by the fructose phosphotransferase system in Salmonella typhimurium.
作者信息
Chin A M, Feucht B U, Saier M H
出版信息
J Bacteriol. 1987 Feb;169(2):897-9. doi: 10.1128/jb.169.2.897-899.1987.
Abstract
A genetic locus designated fruR, previously mapped to min 3 on the Salmonella typhimurium chromosome, gave rise to constitutive expression of the fructose (fru) regulon and pleiotropically prevented growth on all Krebs cycle intermediates. Regulatory effects of fruR were independent of cyclic AMP and its receptor protein and did not prevent uptake of Krebs cycle intermediates. Instead, the phosphotransferase system appeared to regulate gluconeogenesis by controlling the activities of phosphoenolpyruvate carboxykinase and phosphoenolpyruvate synthase.
摘要
一个名为fruR的基因座，先前被定位到鼠伤寒沙门氏菌染色体的3分钟处，它导致果糖（fru）调节子的组成型表达，并多效性地阻止在所有三羧酸循环中间产物上生长。fruR的调节作用不依赖于环腺苷酸及其受体蛋白，也不阻止三羧酸循环中间产物的摄取。相反，磷酸转移酶系统似乎通过控制磷酸烯醇式丙酮酸羧激酶和磷酸烯醇式丙酮酸合酶的活性来调节糖异生作用。
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