Lenasi Helena, Novak Ana, Jug Borut, Dervišević Edvin, Karpljuk Damir, Videmšek Mateja, Sorić Maroje, Hadžić Vedran
Institute of Physiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Sports & Medicine Department, Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia.
Front Physiol. 2022 Mar 31;13:844847. doi: 10.3389/fphys.2022.844847. eCollection 2022.
As cardio-vascular diseases are the leading cause of death worldwide, establishing measures to improve cardiovascular health is of crucial importance. Exercise plays an essential role in cardiac rehabilitation of patients with coronary artery disease (CAD), in whom an evaluation of the cardiorespiratory fitness (CRF) is necessary. CRF of CAD patients could be assessed using 6-min walk test (6MWT), and the results interpreted by using Enright-Sherill prediction equation which has mainly been designed and evaluated for a healthy population. Hypothesizing that the Enright-Sherill prediction equation might not be best suited for CAD patients, our aim was to reevaluate this equation in CAD patients, and potentially establish a more accurate 6MWD prediction equation to be applied in these patients. 6MWD was measured in a cross-sectional study in 67 CAD patients (44 women) who were members of the Coronary club Ljubljana, Slovenia. In addition, the predicted 6MWD was calculated for men and women using Enright-Sherill gender specific regression equation. Multivariate regression analysis was used to obtain a new prediction equation, and the agreement between the measured and the predicted 6MWD analyzed using the repeated measures ANOVA. Men achieved 451 ± 122 m and women 485 ± 69 m without significant differences between sexes (F = 0.022, = 0.882) when adjusted for age, height, body mass, and waist circumference. When comparing the measured (473 ± 91 m) and the predicted (422 ± 57 m) values of 6MWD in CAD patients we found that the Enright-Sherill prediction equation significantly (F = 27.734, < 0.001) underestimated the 6MWD by 52 ± 81 m. A significant regression equation was established [F (3,63) = 44.663, < 0.001], with a of 0.680 where 6MWD equals 1,057 m-4.966 x age (years)-0.614 x WC (cm)-68.629 x NYHA class. The results of this study stress the importance of regular and actual walking ability testing in patients with stable CAD to obtain their CRF, rather than simply predicting it from regression equations obtained from non-representative or non-comparable samples. Our developed prediction equation warrants additional validation and may represent a good substitute for currently used predictions obtained from a healthy population.
由于心血管疾病是全球主要的死亡原因，因此制定改善心血管健康的措施至关重要。运动在冠状动脉疾病（CAD）患者的心脏康复中起着至关重要的作用，对于这类患者，评估心肺适能（CRF）是必要的。CAD患者的CRF可以通过6分钟步行试验（6MWT）进行评估，其结果可使用主要针对健康人群设计和评估的恩赖特 - 谢里尔预测方程来解读。鉴于恩赖特 - 谢里尔预测方程可能并不最适合CAD患者，我们的目的是在CAD患者中重新评估该方程，并有可能建立一个更准确的6MWD预测方程应用于这些患者。在一项横断面研究中，对斯洛文尼亚卢布尔雅那冠心病俱乐部的67名CAD患者（44名女性）进行了6MWD测量。此外，使用恩赖特 - 谢里尔性别特异性回归方程计算了男性和女性的预测6MWD。采用多元回归分析获得一个新的预测方程，并使用重复测量方差分析来分析测量的和预测的6MWD之间的一致性。在对年龄、身高、体重和腰围进行调整后，男性达到451±122米，女性达到485±69米，两性之间无显著差异（F = 0.022，P = 0.882）。当比较CAD患者6MWD的测量值（473±91米）和预测值（422±57米）时，我们发现恩赖特 - 谢里尔预测方程显著（F = 27.734，P < 0.001）低估了6MWD，低估幅度为52±81米。建立了一个显著的回归方程[F（3,63）= 44.663，P < 0.001]，其R²为0.680，其中6MWD等于1057米 - 4.966×年龄（岁） - 0.614×腰围（厘米） - 68.629×纽约心脏病协会（NYHA）分级。本研究结果强调了对稳定CAD患者进行定期和实际步行能力测试以获取其CRF的重要性，而不是简单地根据从非代表性或不可比样本获得的回归方程来预测。我们开发的预测方程需要进一步验证，并且可能是目前从健康人群获得的预测方法的良好替代。
